Kirromycin
Kirromycin structure
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Common Name | Kirromycin | ||
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| CAS Number | 50935-71-2 | Molecular Weight | 796.94300 | |
| Density | 1.279g/cm3 | Boiling Point | 936ºC at 760 mmHg | |
| Molecular Formula | C43H60N2O12 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 519.9ºC | |
Use of KirromycinKirromycin (Mocimycin) is an antibiotic produced by Streptomyces ramocissimus. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome[1][2]. |
| Name | Kirromycin |
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| Synonym | More Synonyms |
| Description | Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces ramocissimus. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.279g/cm3 |
|---|---|
| Boiling Point | 936ºC at 760 mmHg |
| Molecular Formula | C43H60N2O12 |
| Molecular Weight | 796.94300 |
| Flash Point | 519.9ºC |
| Exact Mass | 796.41500 |
| PSA | 228.10000 |
| LogP | 3.46570 |
| Index of Refraction | 1.621 |
| InChIKey | HMSYAPGFKGSXAJ-UHFFFAOYSA-N |
| SMILES | CC=CC=CC1OC(O)(C(CC)C(=O)NCC=CC=C(C)C(OC)C(C)C2OC(C=CC=CC=C(C)C(=O)c3c(O)cc[nH]c3=O)C(O)C2O)C(O)C(O)C1(C)C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | NONH for all modes of transport |
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A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA.
RNA 15(2) , 208-14, (2009) Codon recognition by aminoacyl-tRNA on the ribosome triggers a process leading to GTP hydrolysis by elongation factor Tu (EF-Tu) and release of aminoacyl-tRNA into the A site of the ribosome. The natu... |
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The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365.
FEMS Microbiol. Lett. 319(1) , 26-33, (2011) The main steps in the biosynthesis of complex secondary metabolites such as the antibiotic kirromycin are catalyzed by modular polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS)... |
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Thermodynamic properties of nucleotide-free EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors of its GTPase activity.
Biochim. Biophys. Acta 1597(1) , 22-7, (2002) The thermal transition of elongation factor EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors was studied by differential scanning calorimetry. The effectors of GTPase ... |
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Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary
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Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary
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Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary
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Name: USP28 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 28
External Id: USP28 FAST DUB HTS Primary
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Name: USP10 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 10
External Id: USP10 FAST DUB HTS Primary
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Name: UCHL1 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin C-terminal hydrolase L1
External Id: UCHL1 FAST DUB HTS Primary
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Name: OTUD3 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: OTU deubiquitinase 3
External Id: OTUD3 FAST DUB HTS Primary
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Name: USP30 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 30
External Id: USP30 FAST DUB HTS Primary
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| antibiotic myc-8003 |