915365-57-0

915365-57-0 structure

Name: Cot inhibitor-1
Chemical Name: 6-[[1-[2-(azepan-1-yl)ethyl]triazol-4-yl]methylamino]-8-chloro-4-(3-chloro-4-fluoroanilino)quinoline-3-carbonitrile
CAS Number: 915365-57-0
Molecular Formula: C₂₇H₂₇Cl₂FN₈
Molecular Weight: 553.46100
Catalog: Organic raw materials Organic fluorine compound Fluorobenzonitrile series
Create Date: 2018-12-28 05:40:14
Modify Date: 2026-07-01 18:13:51
Cot inhibitor-1 is a COT/Tpl2 inhibitor.

Name	6-[[1-[2-(azepan-1-yl)ethyl]triazol-4-yl]methylamino]-8-chloro-4-(3-chloro-4-fluoroanilino)quinoline-3-carbonitrile
Synonyms	3-triazol-4-yl]methyl]amino] 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecbonitrile 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azin-1-yl)ethyl]-1H-1 3-Quinolinecbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]Methyl]amino] 6-[[[1-[2-(AZEPAN-1-YL)ETHYL]-1H-1,2,3-TRIAZOL-4-YL]METHYL]AMINO]-8-CHLORO-4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]QUINOLINE-3-CARBONITRILE 6-[[[1-[2-(Azan-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-8-chloro-4-[(3-chloro-4-fluorophenyl)amino]quinoline-3-carbonitrile Cot inhibitor 1,Cot inhibitor1 substituted 6-aminoquinoline-3-carbonitrile,28

Description	Cot inhibitor-1 is a COT/Tpl2 inhibitor.
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References	[1]. Wu, Junjun et al Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-production in human whole blood.Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3485-3488.