288247-87-0
288247-87-0 structure
- Name: T-2513
- Chemical Name: t 2513
- CAS Number: 288247-87-0
- Molecular Formula: C25H27N3O5
- Molecular Weight: 449.49900
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2017-10-17 10:05:26
- Modify Date: 2024-01-10 14:21:35
-
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].
| Name | t 2513 |
|---|
| Description | T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase I |
| In Vitro | SN-38 is the metabolite of T-2513[1]. T-2513 has a broad cytotoxicity against a range of human tumor cell lines[2]. Cell Cytotoxicity Assay[2] Cell Line: WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells Concentration: 15.1-111.5 ng/mL Incubation Time: 24 hours Result: Exhibited cytotoxicity against a panel of human tumor cell lines with GI50s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively. |
| In Vivo | T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma[2]. Animal Model: Rats bearing Walker-256 carcinoma[2] Dosage: 1, 10, and 100 mg/kg Administration: Result: The ED50 was 23 mg/kg. |
| References |
| Molecular Formula | C25H27N3O5 |
|---|---|
| Molecular Weight | 449.49900 |
| Exact Mass | 449.19500 |
| PSA | 116.67000 |
| LogP | 3.06990 |
| Hazard Codes | Xi |
|---|