853299-07-7
853299-07-7 structure
- Name: K 03861
- Chemical Name: k03861
- CAS Number: 853299-07-7
- Molecular Formula: C24H26F3N7O2
- Molecular Weight: 501.504
- Catalog: Research Areas Cancer
- Create Date: 2017-11-24 00:57:40
- Modify Date: 2024-01-10 08:02:10
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K03861 is a type II CDK2 inhibitor with Kd of 8.2 nM.K03861 inhibits CDK2 activity by competing with binding of activating cyclins.
| Name | k03861 |
|---|---|
| Synonyms |
1-{4-[(2-Amino-4-pyrimidinyl)oxy]phenyl}-3-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}urea
1-[4-(2-amino-pyrimidin-4-yloxy)-phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-rifluoromethyl-phenyl]-urea Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]- 1-[4-(2-aminopyrimidine-4-yloxy)phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea |
| Description | K03861 is a type II CDK2 inhibitor with Kd of 8.2 nM.K03861 inhibits CDK2 activity by competing with binding of activating cyclins. |
|---|---|
| Related Catalog | |
| Target |
CDK2(C118L/A144C):9.7 nM (Kd) CDK2(A144C):15.4 nM (Kd) CDK2(C118L):18.6 nM (Kd) CDK2(WT):50 nM (Kd) CDK2(C118L/A144C-Cyclin B):134.1 nM (Kd) |
| References |
[1]. Alexander LT et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H26F3N7O2 |
| Molecular Weight | 501.504 |
| Exact Mass | 501.210022 |
| PSA | 108.64000 |
| LogP | 3.41 |
| Index of Refraction | 1.642 |
| Storage condition | -20℃ |