K 03861
Modify Date: 2024-01-10 08:02:10
K 03861 structure
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Common Name | K 03861 | ||
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| CAS Number | 853299-07-7 | Molecular Weight | 501.504 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H26F3N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of K 03861K03861 is a type II CDK2 inhibitor with Kd of 8.2 nM.K03861 inhibits CDK2 activity by competing with binding of activating cyclins. |
| Name | k03861 |
|---|---|
| Synonym | More Synonyms |
| Description | K03861 is a type II CDK2 inhibitor with Kd of 8.2 nM.K03861 inhibits CDK2 activity by competing with binding of activating cyclins. |
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| Related Catalog | |
| Target |
CDK2(C118L/A144C):9.7 nM (Kd) CDK2(A144C):15.4 nM (Kd) CDK2(C118L):18.6 nM (Kd) CDK2(WT):50 nM (Kd) CDK2(C118L/A144C-Cyclin B):134.1 nM (Kd) |
| References |
[1]. Alexander LT et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H26F3N7O2 |
| Molecular Weight | 501.504 |
| Exact Mass | 501.210022 |
| PSA | 108.64000 |
| LogP | 3.41 |
| Index of Refraction | 1.642 |
| Storage condition | -20℃ |
| 1-{4-[(2-Amino-4-pyrimidinyl)oxy]phenyl}-3-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}urea |
| 1-[4-(2-amino-pyrimidin-4-yloxy)-phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-rifluoromethyl-phenyl]-urea |
| Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]- |
| 1-[4-(2-aminopyrimidine-4-yloxy)phenyl]-3-[4-(4-methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]urea |