Name | 1-[6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-2-carboxylic acid |
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Synonyms |
Ceranapril
CERONAPRIL SQ-29,852 Ceronaprilum |
Description | Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC50 of 36 nM[1]. |
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Related Catalog | |
Target |
IC50: 36 nM (ACE)[1] |
In Vivo | Ceronapril (SQ 29852) 在雄性 SD 大鼠中抑制 ACE,静脉注射和口服的 ED50 分别为 0.063 μM/kg 和 0.53 μM/kg[1]。 Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) 阻断大鼠外周部位的 ACE [2]。 Animal Model: Male Sprague-Dawley rats[2] Dosage: 100 mg/kg Administration: PO, twice daily for 3 days or single daily dose Result: Showed clear inhibition of ACE in the 2 circumventricular organs-the subfornical organ and the lamina terminals-but no change in other regions of the brain after chronic treatment. Inhibited ACE in plasma, kidney and lung rapidly (3 hr) after a single administration. Did not inhibit ACE in structures of the brain within the blood-brain barrier, such as the caudate-putamen, choroid plexus, globus pallidus, supraoptic nucleus and paraventricular nucleus of the hypothalamus. |
References |
Density | 1.265g/cm3 |
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Boiling Point | 682.8ºC at 760 mmHg |
Molecular Formula | C21H33N2O6P |
Molecular Weight | 440.47000 |
Flash Point | 366.7ºC |
Exact Mass | 440.20800 |
PSA | 139.97000 |
LogP | 3.42270 |
Vapour Pressure | 1.4E-19mmHg at 25°C |
Index of Refraction | 1.559 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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