Shanghai Nianxing Industrial Co., Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
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Henan Tianfu Chemical Co., Ltd.
China
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: HEPPS
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16052-06-5

16052-06-5 structure

16052-06-5 structure

Name: HEPPS
Chemical Name: hepps
CAS Number: 16052-06-5
Molecular Formula: C₉H₂₀N₂O₄S
Molecular Weight: 252.331
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-09 08:00:00
Modify Date: 2026-07-02 14:45:45
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].

Name	hepps
Synonyms	PS SIGMAULTRA HPS CELL CULTURE CRYSTALLINE 4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID;PS PS (4-(2-HYDROXYETHYL)-1-PIPERAZINE -PROPANESULFONIC ACID) ULTRA BUFFER ADE 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINE]PROPANESULFONIC ACID 4-(2-HYDROXYETHYL)-1-PIPERAZINROPANESULFONIC ACID PS N-(2-HYDROXYETHYL)-N'-(3-SULFOPROPYL)-PIPERAZINE MFCD00006160 PS, (4-(2-HYDROXYETHYL)-1-PIPERAZI NE -PROPANESULFONIC ACID) 3-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]PROPANESULFONIC ACID 4-(2-Hydroxyethyl)pi 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid 4-(2-Hydroxyethyl)-1-piperazinropanesulfonic acid[HPS] HPS ULTRAPURE 4-(2-Hydroxyethyl)-1-piperazinropanesulfonic Acid HPS 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid HpsN-(2-Hydroxyethyl)Piperazine-NPropanesulfonicAcid N-(hydroxyethyl)piperazine-N’-propanesulfonic acid (HPS) 1-Piperazinropanesulfonic acid, 4-(2-hydroxyethyl) N-(2-Hydroxyethyl)piperazine-N'-3-propanesulphonic acid 4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID 3-[4-(2-Hydroxyethyl)piperazino]-1-propanesulfonic acid aPS HPS N-(2-Hydroxyethyl)piperazine-N-3-propanesulfonic acid 4-Hydroxyerhylpiperazine-1-propanesulfonic acid HPSPS) ps for biochemistry HPS, ULTROL ade N-(2-Hydroxyethyl)piperazine-N'-(propanesulphonic acid) HPS~4-(2-Hydroxyethyl)-1-piperazinropanesulphonic acid PS, for biochemistry 3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic acid 4-(2-Hydroxyethyl)-1-piperazinropane-1-sulfonic acid PS Vetec(TM) ade HPS/PS/HE HPS Buffer 3-[4-(2-Hydroxyethyl)piperazine-1-yl]-1-propanesulfonic acid ps(N-[2-Hydroxyethyl]Piperazine-N3-PropaneSulfonicAcid]) EPPS 4-(2-Hydroxyethyl)-1-piperazinropanesulfonic acid, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, HPS, N-(2-Hydroxyethyl)piperazine-Nμ-(3-propanesulfonic acid) 4-(2-hydroxyethyl)-1-piperazinropanesulphonic acid [2-hydroxyethyl]piperazine-n’-[3-propancesulfonicacid] 3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic N-(Hydroxyethyl)piperazine-N'-propane sulfonic acid PS FREE ACID, BIOTECHNOLOGY PERFORMANC E CERTIFIED 3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-propanesulfonic acid 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component 4-(2-hydroxyethyl)-1-piperazinropanesulfonicaci N-2-HYDROXYETHYLPIPERAZINE-N'-3-PROPANESULPHONIC ACID 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid N-[2-HYDROXYETHYL]PIPERAZINE-N'-[3-PROPANESULFONIC ACID] HPS/ 4-(2-Hydroxyethyl)-1-piperazinropanesulfonic acid Hydroxyethyl)piperazine-N'-3-propane-sulfonic acid 4-(2-Hydroxyethyl)-1-piperazinropanesulfonic Acid [Good's buffer component for biological ] EINECS 240-198-8 LABOTEST-BB LT00138110 HPS (4-(2-HYDROXYETHYL)PIPERAZINE-1-PROPANESULFONIC ACID) HPS, (T)

Description	HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997.

Density	1.3±0.1 g/cm3
Melting Point	237-239 °C(lit.)
Molecular Formula	C₉H₂₀N₂O₄S
Molecular Weight	252.331
Exact Mass	252.114380
PSA	89.46000
LogP	-2.46
Index of Refraction	1.537
Storage condition	Store at RT.
Water Solubility	H2O: 1 M at 20 °C, clear, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2649130

CHEMICAL NAME :: 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 16052-06-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H20-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TM2649130
HS Code	29335995

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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