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Related CAS#:
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32887-01-7

32887-01-7 structure
32887-01-7 structure
  • Name: Mecillinam
  • Chemical Name: mecillinam
  • CAS Number: 32887-01-7
  • Molecular Formula: C15H23N3O3S
  • Molecular Weight: 439.569
  • Catalog: API Antibiotics Penicillin
  • Create Date: 2018-03-11 08:00:00
  • Modify Date: 2024-01-02 10:38:54
  • Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms[1].
Name mecillinam
Synonyms 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1E)-(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (5R,6R)-
[(2,2-Dimethylpropanoyl)oxy]methyl (5R,6R)-6-[(E)-(1-azepanylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Amdinocillin
Mecillinam
EINECS 251-277-1
MFCD00056869
Description Mecillinam (Amdinocillin), the β-lactam antibiotic, has a broad spectrum of activity against gram-negative organisms[1].
Related Catalog
In Vivo Mecillinam (Amdinocillin, 400 mg per kg) is effective for the treatment of catheterassociated infections at high dosages (400 mg per kg of body weight/d)[1]. Animal Model: Mecillinam (Amdinocillin, 400 mg per kg) is effective for the treatment of catheterassociated infections at high dosages (400 mg per kg of body weight/d)[1]. Dosage: 50, 100, 200, and 400 mg per kg. Administration: Intravenously each day in four divided doses over a 72-h period. Result: High dose of 400 mg/kg exhibited significant activity.
References

[1]. M E Olson, et al. Amdinocillin Treatment of Catheter-Associated Bacteriuria in Rabbits. J Infect Dis. 1989 Jun;159(6):1065-72.
Density 1.3±0.1 g/cm3
Boiling Point 581.0±60.0 °C at 760 mmHg
Melting Point 156°C
Molecular Formula C15H23N3O3S
Molecular Weight 439.569
Flash Point 305.2±32.9 °C
Exact Mass 439.214081
PSA 98.51000
LogP 2.97
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.604
Storage condition Store at?0-5°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI0185000
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((hexahydro-1H-azepin-1-yl)methylene) amino)-3,3-dimethyl-7-oxo-, (+)-
CAS REGISTRY NUMBER :
32887-01-7
LAST UPDATED :
199512
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C15-H23-N3-O3-S
MOLECULAR WEIGHT :
325.47
WISWESSER LINE NOTATION :
T45 ANV ESTJ F1 F1 GVQ CNU1- AT7NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 9,91,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 9,91,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,191,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 9,91,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 9,91,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,191,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
130 gm/kg/26W-I
TOXIC EFFECTS :
Blood - normocytic anemia Liver - changes in liver weight Related to Chronic Data - changes in testicular weight
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 9,91,1980
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
RTECS XI0185000
551-16-6 structure

551-16-6

65009-95-2 structure

65009-95-2

~%

32887-01-7 structure

32887-01-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 35, # 2 p. 642 - 646
Precursor  2

DownStream  0


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