CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SF7960000
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CHEMICAL NAME :
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Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-, chloride
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CAS REGISTRY NUMBER :
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602-52-8
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LAST UPDATED :
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199606
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C21-H20-N3.Cl
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MOLECULAR WEIGHT :
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349.89
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WISWESSER LINE NOTATION :
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T B666 HKJ EZ H2 IR& LZ &Q &G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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21 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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56370 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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14 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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17640 ug/kg/28D-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - chronic pulmonary edema Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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17640 ug/kg/28D-I
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: -,107,1965
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