1035438-80-2

1035438-80-2 structure

Name: Risedronic Acid-d4
Chemical Name: 1-hydroxy-2-([2,4,5,6-2H4]-pyridin-3-yl)ethylidene-1,1-bisphosphonic acid
CAS Number: 1035438-80-2
Molecular Formula: C₇H₇D₄NO₇P₂
Molecular Weight: 287.13700
Catalog: Research Areas Others
Create Date: 2017-10-05 14:48:02
Modify Date: 2024-01-08 15:25:33
Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].

Name	1-hydroxy-2-([2,4,5,6-2H4]-pyridin-3-yl)ethylidene-1,1-bisphosphonic acid
Synonyms	risedronic acid-d4 Risedronic acid-d4

Description	Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Giljevic Z, et al. Treatment of osteoporosis by risedronate-- speed, efficacy and safety. Reumatizam. 2006;53(2):66-71. [3]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.