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Product Name: Formamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
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7411-12-3

7411-12-3 structure

7411-12-3 structure

Name: Formamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
Chemical Name: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
CAS Number: 7411-12-3
Molecular Formula: C₂₁H₂₃NO₆
Molecular Weight: 385.41000
Create Date: 2018-06-20 22:18:28
Modify Date: 2025-09-04 21:28:21

Name	N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
Synonyms	Formyldescaetylcolchicine,N N-deacetyl-N-formylcolchicine N-Formyldeacetylcolchicine N-Desacetyl-N-formyl-colchicin COLCHICINE,N-DEACETYL-N-FORMYL N-((S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamid Gloriosine N-formyl-N-deacetylcolchicine N-Formyldesacetylcolchicine (S)-7-Formylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamide

Density	1.27g/cm3
Boiling Point	715.8ºC at 760 mmHg
Melting Point	264-267ºC
Molecular Formula	C₂₁H₂₃NO₆
Molecular Weight	385.41000
Flash Point	386.7ºC
Exact Mass	385.15300
PSA	83.09000
LogP	3.50830
Index of Refraction	1.591

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0794000

CHEMICAL NAME :: Colchicine, N-deacetyl-N-formyl-

CAS REGISTRY NUMBER :: 7411-12-3

BEILSTEIN REFERENCE NO. :: 2824080

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMVH NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 33,1606,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4400 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2666 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9200 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

HS Code	2924299090

64-18-6 structure

64-18-6

3476-50-4 structure

3476-50-4

~%

7411-12-3 structure

7411-12-3

Literature: Raffauf et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 3854

186581-53-3 structure

186581-53-3

~%

7411-12-3 structure

7411-12-3

Literature: Santavy; Reichstein Helvetica Chimica Acta, 1950 , vol. 33, p. 1606,1625

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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