51776-33-1

51776-33-1 structure

Name: LHRH (4-10) acetate salt
Chemical Name: 1-[2-[[2-[[2-[[2-[(2-amino-3-hydroxypropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide$GLP-HIS-TYR-SER-LEU-GLU-TRP-LYS-PRO-GLY-NH2
CAS Number: 51776-33-1
Molecular Formula: C₃₃H₅₃N₁₁O₉
Molecular Weight: 747.84200
Catalog: Signaling Pathways GPCR/G Protein GNRH Receptor
Create Date: 2018-12-14 18:19:17
Modify Date: 2024-01-12 00:20:23
LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes[1].

Name	1-[2-[[2-[[2-[[2-[(2-amino-3-hydroxypropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide$GLP-HIS-TYR-SER-LEU-GLU-TRP-LYS-PRO-GLY-NH2
Synonyms	Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 Luteinizing hormone releasing hormone Fragment 4-10 LH-RH Fragment 4-10 LHRH (4-10) H-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Description	LH-RH (4-10) is a heptapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (4-10) produced in macrophages and type II pneumocytes[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Endocrinology
In Vitro	The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor)[1]. LH-RH (4-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 23 pM[2].