85344-77-0

85344-77-0 structure

Name: Pyr-His-Pro-Gly-OH
Chemical Name: TRH-Gly
CAS Number: 85344-77-0
Molecular Formula: C₁₈H₂₄N₆O₆
Molecular Weight: 420.42000
Catalog: Research Areas Endocrinology
Create Date: 2018-12-26 05:30:08
Modify Date: 2024-01-12 21:17:05
Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin[1].

Name	TRH-Gly
Synonyms	PE-H-P-G PYR-HIS-PRO-GLY-OH THYROTROPIN-RELEASING HORMONE-GLY pglu-his-pro-gly PYR-HIS-PRO-GLY GLP-HIS-PRO-GLY

Description	Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Thyroid Hormone Receptor
In Vitro	在表达内源性 TRH-R 的 GH3 细胞中，Trh-gly 引起细胞内钙浓度的立即升高，表明 Trh-gly 直接反应而不从 Trh-gly 转化为 TRH[2]。
In Vivo	在聚氨酯麻醉的 2 个月大（250 克）雄性 Sprague-Dawley 大鼠中，Trh-gly（脑池内注射；1.0 mg）导致下丘脑、延髓和血液中的 TRH 水平显着增加[1]。
References	[1]. A E Pekary, et al. Release of thyrotropin and prolactin by a thyrotropin-releasing hormone (TRH) precursor, TRH-Gly: conversion to TRH is sufficient for in vivo effects. Neuroendocrinology. 1990 Dec;52(6):618-25. [2]. M Yamada, et al. Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly. Neurosci Lett. 1995 Aug 18;196(1-2):109-12.