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5943-62-4

5943-62-4 structure
5943-62-4 structure
  • Name: Tetraethyl decane-1,10-diylbis(phosphonate)
  • Chemical Name: 1,10-bis(diethoxyphosphoryl)decane
  • CAS Number: 5943-62-4
  • Molecular Formula: C18H40O6P2
  • Molecular Weight: 414.45400
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-05-15 08:00:00
  • Modify Date: 2024-01-09 06:27:28
  • Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 1,10-bis(diethoxyphosphoryl)decane
Synonyms 1,10-Bis-(O,O-diethyl-phosphono)-decan
Decan-diphosphonsaeure-(1,10)-tetraethylester
tetraethyl decane-1,10-diyldiphosphonate
TETRAETHYL DECAMETHYLENEDIPHOSPHONATE
Decamethylen-bis-(diethylphosphonat)
tetra-ethyl decylene diphosphonate
Description Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C18H40O6P2
Molecular Weight 414.45400
Exact Mass 414.23000
PSA 90.68000
LogP 6.63940