Tetraethyl decane-1,10-diylbis(phosphonate)

Modify Date: 2024-01-09 06:27:28

Tetraethyl decane-1,10-diylbis(phosphonate) Structure
Tetraethyl decane-1,10-diylbis(phosphonate) structure
Common Name Tetraethyl decane-1,10-diylbis(phosphonate)
CAS Number 5943-62-4 Molecular Weight 414.45400
Density N/A Boiling Point N/A
Molecular Formula C18H40O6P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tetraethyl decane-1,10-diylbis(phosphonate)


Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1,10-bis(diethoxyphosphoryl)decane
Synonym More Synonyms

  Biological Activity

Description Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C18H40O6P2
Molecular Weight 414.45400
Exact Mass 414.23000
PSA 90.68000
LogP 6.63940

 Synonyms

1,10-Bis-(O,O-diethyl-phosphono)-decan
Decan-diphosphonsaeure-(1,10)-tetraethylester
tetraethyl decane-1,10-diyldiphosphonate
TETRAETHYL DECAMETHYLENEDIPHOSPHONATE
Decamethylen-bis-(diethylphosphonat)
tetra-ethyl decylene diphosphonate