40733-27-5

40733-27-5 structure

Name: 3'-O-TBDMS-dT
Chemical Name: 1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
CAS Number: 40733-27-5
Molecular Formula: C₁₆H₂₈N₂O₅Si
Molecular Weight: 356.49
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-05-07 22:24:04
Modify Date: 2026-07-16 18:07:14
3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Synonyms	3'-O-(tert-ButyldiMethylsilyl)thyMidine 1-((2R,4S,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 3'-O-tert-butyldiMethylsilyl-2'-deoxythyMidine 3'-O-t-BulyldiMethylsilyl thyMidine 3'-O-TBDMS-2'-dT Thymidine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl] 3'-DiTBSRiboT 3'-O-(TBDMS)THYMIDINE 3'-O-(T-BUTYLDIMETHYLSILYL)THYMIDINE TBS-T 3’-O-t-Bulyldimethylsilyl thymidine 3'-O-[tert-Butyl(dimethyl)silyl]thymidine

Description	3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.