Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Promazine hydrochloride
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Purity: 98.0%
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53-60-1

53-60-1 structure

Name: Promazine hydrochloride
Chemical Name: promazine hydrochloride
CAS Number: 53-60-1
Molecular Formula: C₁₇H₂₁ClN₂S
Molecular Weight: 320.88000
Catalog: API Nervous system medication Antipsychotic
Create Date: 2018-06-22 16:05:08
Modify Date: 2026-07-01 19:52:13
Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.

Name	promazine hydrochloride
Synonyms	10-(3-(dimethylamino)propyl)-phenothiazinhydrochloride n,n-dimethyl-10h-phenothiazine-10-propanamine hydrochloride Sinophenin hydrochloride PROMAZINE HCL //BP Spine Talofen 10-(gamma-Dimethylamino-n-propyl)phenothiazine hydrochloride Chlorpromazine Impurity C（） Chlorpromazine impurity C Romtiazin hydrochloride N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine,hydrochloride Propazin (phmaceutical) Promazine hydrochloride, 10 mM in DMSO Chlorpromazine Impurity C HCl Spine hydrochloride Promazine hydrochloride CRS Promazine monohydrochloride Stazin 10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride Promazine HCl (Chlorpromazine Impurity CHCl) Prazine ProMazine hydrochloride PROMAZINE HCL Promazine HydrochlorideQ: What is Promazine Hydrochloride Q: What is the CAS Number of Promazine Hydrochloride Q: What is the storage condition of Promazine Hydrochloride Q: What e the applications of Promazine Hydrochloride tianfu-chem_ Promazine hydrochloride -1 N-(3-(Dimethylamino)propyl)phenothiazine hydrochloride N,N-DiMethyl-3-(10H-phenothiazin-10-yl)propan-1-aMine hydrochloride Verophen C16345700 PromazinEhydrochloride PROMAZINE HYDROCHLORIDE VETRANAL Promazine hydrochloride //BP Liranol Phenothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride 10-(3-Dimethylaminopropyl)phenothiazine hydrochloride Chlorpromazine Impurity 3 HCl(Chlorpromazine Impurity C HCl) Promazine hydrochloride in methanol Prolactyl N,N-Dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride n,n-dimethyl-10h-phenothiazine-10-propanaminmonohydrochloride 10-(gamma-dimethylamino-n-propyl)phenothiazinehydrochloride component of Ketaset plus (veteriny) Promwill Espinal Promazine Hydrochloride 10-(3-(dimethylamino)propyl)phenothiazinemonohydrochloride chlorowodorekpromazyny Romtiazin hydrochloride\|\|\|Sinophenin hydrochloride Chlorpromazine Hydrochloride Impurity C as Hydrochloride 10-(3-(dimethylamino)propyl)-phenothiazinmonohydrochloride 10-(3-(Dimethylamino)propyl)phenothiazine monohydrochloride Chlorpromazine impurity 4/Chlorpromazine Impurity C/Promazine HCl/N,N-Dimethyl-10H-phenothiazine-10-propanamine hydrochloride 10-[3-(DIMETHYLAMINO)PROPYL]-PHENOTHIAZINE HYDROCHLORIDE Chlorpromazine-003-HCl Verofen Megaphen Phenothiazine, 10-(3-(dimethylamino)propyl)-, hydrochloride MFCD00058535 rp4560 N,N-dimethyl-3-(10H-phenothiazin-10-yl) EINECS 200-179-7

Description	Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease

Boiling Point	412.7ºC at 760mmHg
Melting Point	174-176ºC
Molecular Formula	C₁₇H₂₁ClN₂S
Molecular Weight	320.88000
Flash Point	203.4ºC
Exact Mass	320.11100
PSA	31.78000
LogP	5.10800
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO8575000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 53-60-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C17-H20-N2-S.Cl-H

MOLECULAR WEIGHT :: 320.91

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 20 mg/kg/D-I

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - tremor Behavioral - antipsychotic

REFERENCE :: JNMDAN Journal of Nervous and Mental Disease. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.3- 1876- Volume(issue)/page/year: 123,553,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 5,269,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 356 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,295,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APMCB4 Annales Pharmaceutic. (Poznan, Poland) V.3-13, 1965-78. Discontinued. Volume(issue)/page/year: 13,51,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,-,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3224 No. of Facilities: 57 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1876 (estimated) No. of Female Employees: 940 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H317
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R43
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SO8575000
HS Code	2934300000

67-56-1

69-09-0

~38%

61-01-8

53-60-1

Literature: Garcia, Carmelo; Pinero, Luis; Oyola, Rolando; Arce, Rafael Photochemistry and Photobiology, 2009 , vol. 85, # 1 p. 160 - 170

71-23-8

69-09-0

~82%

1156505-40-6

53-60-1

Literature: Garcia, Carmelo; Pinero, Luis; Oyola, Rolando; Arce, Rafael Photochemistry and Photobiology, 2009 , vol. 85, # 1 p. 160 - 170

64-17-5

69-09-0

~64%

94437-15-7

53-60-1

Literature: Garcia, Carmelo; Pinero, Luis; Oyola, Rolando; Arce, Rafael Photochemistry and Photobiology, 2009 , vol. 85, # 1 p. 160 - 170

69-09-0

67-63-0

~88%

1156505-41-7

53-60-1

Literature: Garcia, Carmelo; Pinero, Luis; Oyola, Rolando; Arce, Rafael Photochemistry and Photobiology, 2009 , vol. 85, # 1 p. 160 - 170

69-09-0

56-81-5

53-60-1

Literature: Organic Mass Spectrometry, , vol. 29, # 1 p. 18 - 25

Precursor 6
67-56-1 69-09-0 71-23-8 64-17-5
67-63-0 56-81-5
DownStream 0

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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