23062-24-0
23062-24-0 structure
- Name: EURYCOMALACTONE(P)
- Chemical Name: Eurycomalactone
- CAS Number: 23062-24-0
- Molecular Formula: C19H24O6
- Molecular Weight: 348.390
- Catalog: Research Areas Others
- Create Date: 2016-04-23 14:20:42
- Modify Date: 2025-08-25 23:55:29
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Eurycomalactone is a natural product found in Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor, with an IC50 of 0.5 μM. Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα[1].
| Name | Eurycomalactone |
|---|---|
| Synonyms | (1S,2R,5S,9S,10S,11R,12R,13R,16R)-9,12-Dihydroxy-2,6,10,16-tetramethyl-14-oxatetracyclo[11.2.1.0.0]hexadec-6-ene-3,8,15-trione |
| Description | Eurycomalactone is a natural product found in Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor, with an IC50 of 0.5 μM. Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.5 μM (NF-κB)[1] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 588.1±50.0 °C at 760 mmHg |
| Melting Point | 268-270 °C |
| Molecular Formula | C19H24O6 |
| Molecular Weight | 348.390 |
| Flash Point | 213.1±23.6 °C |
| Exact Mass | 348.157288 |
| PSA | 100.90000 |
| LogP | -0.43 |
| Vapour Pressure | 0.0±3.7 mmHg at 25°C |
| Index of Refraction | 1.576 |
| Hazard Codes | Xi |
|---|