4342-03-4
4342-03-4 structure
- Name: Dacarbazine
- Chemical Name: dacarbazine
- CAS Number: 4342-03-4
- Molecular Formula: C6H10N6O
- Molecular Weight: 182.183
- Catalog: API Antineoplastic agents Alkylating agent
- Create Date: 2018-02-06 08:00:00
- Modify Date: 2026-07-01 20:20:33
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Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.Target: Nucleoside antimetabolite/analogApproved: May 1975Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in advanced previously untreated pancreatic islet cell tumors [2]. In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P = .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75) [3].
| Name | dacarbazine |
|---|---|
| Synonyms |
5-(3,3'-DIMETHYL-1-TRIAZENO)IMIDAZOLE-4-CBOXAMIDE
5-(3,3-dimethyltriazeno)imidazole-4-cboxamide 4-(3,3-dimethyltriazeno)imidazole-5-cboxamide Dtic-Dome DTIC DTIE biocbaziner Dacbazine SynonyMs 5-(3,3-DiMethyl-1-triazenyl)iMidazole-4-cboxaMide Dacbazine DACBAZINE, ANTINEOPLASTIC PURINE A 1H-Imidazole-4-cboxamide, 5-(3,3-dimethyl-1-triazen-1-yl) 5-(3,3-dimethyl-1-triazen-1-yl)-1H-imidazole-4-cboxamide (dimethyltriazeno)imidazolecboxamide DACBAZINE RELATED COMPOUND B 2-AZAHYPOXANTHINE (CRM STANDD) acbazine 4-04 Of kappa oxazine nci-c04717 DACBAZINE STANDD EINECS 224-396-1 4-(dimethyltriazeno)imidazole-5-cboxamide 5-[(1E)-dimethyltriaz-1-en-1-yl]-1H-imidazole-4-cboxamide high quality Dacbazine 5-(dimethyltriazeno)imidazole-4-cboxamide NSC-45388 4-[(1E)-3,3-Dimethyl-1-triazen-1-yl]-1H-imidazole-5-carboxamide 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-cboxamide, DTIC 4-(3,3-dimethyl-1-triazeno)imidazole-5-cboxamide dtic-aome DICBAZINE Dacbazine CRS Dacbazine> 5-(3,3-DIMETHYL-1-TRIAZENYL)-1H-IMIDAZOLE-4-CBOXAMIDE 5-(3,3-dimethyl-1-triazeno1-imidazole-4-cboxamid 5-[3,3-DIMETHYL-1-TRIAZENYL]IMIDAZOLE-4-CBOXAMIDE DACBAZINE BP STANDD 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide,DTIC Dacbazine, (LC&T 5-(3,3-dimethyl-l-triazenyl)imidazole-4-carboxamide Dacbazin Dacbazine,5-(3,3-Dimethyl-1-triazenyl)imidazole-4-cboxamide, DTIC 5-(3,3-dimethyltriazen-1-yl)-imidazole-4-carboxamide DTIC Dome DICARBAZINE Dacbazine //BP 5-(3,3-dimethyl-1-triazenyl)imidazole-4-carboxamide (5E)-5-(dimethylaminohydrazinylidene)-4-imidazolecboxamide Dncbazine DIC TOSLAB 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide Dacbazine (DTIC) DACBAZINE(DTIC-DOME; DTIC) DacbazineQ: What is Dacbazine Q: What is the CAS Number of Dacbazine Q: What is the storage condition of Dacbazine Q: What e the applications of Dacbazine DACBAZINE RELATED COMPOUND A 5-AMINOIMIDAZOLE-4-CBOXAMIDE HCL (CRM STANDD) 5-(3,3-dimethyl-1-triazeno)-imidazole-4-cboxamid dtic-dome 5-(3,3-Dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide 5-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide 5-(3,3-dimethyl-1-triazenyl)-1h-imidazole-4-cboxamid 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide DTIC DTIC 5-(3,3-Dimethyltriazeno)imidazole-4-cboxamide 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-cb oxamide MFCD00057167 (E)-5-(3,3-diMethyltriaz-1-en-1-yl)-1H-iMidazole-4-cboxaMide 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide Dacbazine(DTIC-Dome deticene 5-(3,3-Dimethyl-1-triazeno)imidazole-4-cboxamide (Dacbazine) |
| Description | Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.Target: Nucleoside antimetabolite/analogApproved: May 1975Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in advanced previously untreated pancreatic islet cell tumors [2]. In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P = .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75) [3]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 456.3±55.0 °C at 760 mmHg |
| Melting Point | 199-205°C |
| Molecular Formula | C6H10N6O |
| Molecular Weight | 182.183 |
| Flash Point | 229.7±31.5 °C |
| Exact Mass | 182.091614 |
| PSA | 99.73000 |
| LogP | -0.28 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.678 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332-H315-H319-H335-H340-H350 |
| Precautionary Statements | P201-P261-P280-P305 + P351 + P338-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R45;R46;R20/21/22;R36/37/38 |
| Safety Phrases | S53-S36/37/39-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NI3950000 |
| HS Code | 2933290090 |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |