75695-93-1

75695-93-1 structure

Name: Isradipine
Chemical Name: Isradipine
CAS Number: 75695-93-1
Molecular Formula: C₁₉H₂₁N₃O₅
Molecular Weight: 371.387
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-02-24 08:00:00
Modify Date: 2026-07-02 18:10:08
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.Target: Calcium ChannelIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack[1]. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension [2].

Name	Isradipine
Synonyms	Isradipine Solution, 100ppm Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylate [R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic acid 3-methyl 5-(1-methylethyl) ester 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic acid 3-methyl 5-(1-methylethyl) ester Isradipine, >= 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecboxylicacidmethyl1-methylethylester 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic[chemicalname]acidmethyl1-methylethylester DynaCirc 3-Methyl 5-propan-2-yl (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicboxylate 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester (9CI) Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylate 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICBOXYLIC ACID METHYL 1-METHYLETHYL ESTER MFCD00153820 Rebfiden Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Isradipine> Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate Dynacirc CR 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonyl-pyridine-5-carboxylic acid methyl ester Clivoten 3,5-Pyridinedicboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester Lomir 4-(2,1,3-benzoxadiazol-4-yl)-2,6-diméthyl-1,4-dihydropyridine-3,5-dicarboxylate de méthyle et de 1-méthyléthyle Isradipine CRS 3-Isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic [chemical name] acid methyl 1-methylethyl ester Methyl-1-methylethyl-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarboxylat Prescal (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicboxylic acid O3-methyl ester O5-propan-2-yl ester isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate 4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECBOXYLIC ACID METHYL 1-METHYLETHYL ESTER 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic Acid Isopropyl Methyl Ester PN ;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR Rebriden Isradipine(Dynacirc) 4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester Esradin Isrodipine 4-(2,1,3-Benzooxadiazol-4-yl)-2.6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester Presca Isradipine //BP 3,5-Pyridinedicboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester PN-200-110 Dynacrine Isradipine in methanol Isradipine for peak identification CRS 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic AcidMethyl 1-Methylethyl Ester Iomir methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Isradipine, 10 mM in DMSO UNII:YO1UK1S598 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-pyridine-5-carboxylic acid isopropyl ester Isradipine API 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester Isradipine, L-type Ca2+ channel blocker 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicboxylic acid 3-methyl 5-isopropyl ester 4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicboxylic acid methyl 1-methylethyl ester PN-200-100 Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet methyl 1-methylethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate IsradipineQ: What is Isradipine Q: What is the CAS Number of Isradipine Q: What is the storage condition of Isradipine Q: What e the applications of Isradipine Isradipin

Description	Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.Target: Calcium ChannelIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack[1]. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension [2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Berjukow, S. and S. Hering, Voltage-dependent acceleration of Ca(v)1.2 channel current decay by (+)- and (-)-isradipine. Br J Pharmacol, 2001. 133(7): p. 959-66. [2]. Tran, P.H., et al., Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion. Int J Pharm, 2013. 450(1-2): p. 79-86.

Density	1.3±0.1 g/cm3
Boiling Point	501.9±60.0 °C at 760 mmHg
Melting Point	166-168°C
Molecular Formula	C₁₉H₂₁N₃O₅
Molecular Weight	371.387
Flash Point	257.4±32.9 °C
Exact Mass	371.148132
PSA	103.55000
LogP	3.59
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.566
Storage condition	2-8°C
Water Solubility	DMSO: ~26 mg/mL

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

104785-90-2

40100-28-5

75695-93-1

Literature: WO2005/5437 A1, ; Page/Page column 7-9 ;

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2172135-50-9	2228572-57-2
2171150-16-4	2172469-41-7
2171621-86-4	2172506-66-8
2171976-33-1	2171418-28-1
2171150-23-3	2227925-30-4