19428-14-9
19428-14-9 structure
- Name: UNII:S831Z48C5W
- Chemical Name: Benproperine Phosphate
- CAS Number: 19428-14-9
- Molecular Formula: C21H30NO5P
- Molecular Weight: 407.440
- Catalog: API Respiratory medication Antitussive
- Create Date: 2018-04-25 08:00:00
- Modify Date: 2024-01-02 14:19:57
-
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis[1].
| Name | Benproperine Phosphate |
|---|---|
| Synonyms |
Piperidine, 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-, phosphate (1:1)
1-[1-(2-Benzylphenoxy)propan-2-yl]piperidine phosphate (1:1) EINECS 243-050-0 UNII:S831Z48C5W 1-[1-(2-Benzylphenoxy)-2-propanyl]piperidine phosphate (1:1) 1-(1-Methyl-2-(2-benzylphenoxy)ethyl)piperidine phosphate Piperidine, 1-(1-methyl-2-(2-benzylphenoxy)ethyl)-, phosphate Benproperine phosphate MFCD01700461 |
| Description | Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Benproperine phosphate (20-120 μM; for 24 hours) inhibits cell viability in a dose-dependent manner[1]. Benproperine phosphate (10 μM; for 24 hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC50 values of 1-2 μM. Benproperine phosphate (10 μM; for 24 hours) does not affect cortactin-rich lamellipodium in MCF-10A cells[1]. Cell Viability Assay[1] Cell Line: DLD-1, AsPC-1, CFPAC-1, A375P, A375P, MDA-MB-231, DU145, DU145 cancer cells Concentration: 20, 40, 60, 80, 100, 120 μM Incubation Time: For 24 hours Result: Inhibited cell viability in a dose-dependent manner. |
| In Vivo | Benproperine phosphate (50, 100 mg/kg; oral gavage; 5 days per week for 4 weeks) inhibits primary pancreatic tumor growth[1]. Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%[1]. Animal Model: Female BALB/c nude mice of 6-week-old with AsPC-1 cells[1] Dosage: 50, 100 mg/kg Administration: Oral gavage; 5 days per week for 4 weeks Result: Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change. |
| References |
| Boiling Point | 433ºC at 760mmHg |
|---|---|
| Melting Point | 148-153ºC |
| Molecular Formula | C21H30NO5P |
| Molecular Weight | 407.440 |
| Exact Mass | 407.186157 |
| PSA | 100.04000 |
| LogP | 3.53990 |
| Vapour Pressure | 1.06E-07mmHg at 25°C |
| Storage condition | 2-8°C |