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536-43-6

536-43-6 structure
536-43-6 structure
  • Name: Dyclonine hydrochloride
  • Chemical Name: dyclonine hydrochloride
  • CAS Number: 536-43-6
  • Molecular Formula: C18H28ClNO2
  • Molecular Weight: 325.873
  • Catalog: API Anesthetic Agents Local anesthetics
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2024-01-02 17:57:35
  • Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.Target: Sodium ChannelDyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt. Dyclonine hydrochloride has been found to possess, in addition to its topical anesthetic properties, significant bactericidal and fungicidal activity. Self-sterilizing action manifested by preparations containing the drug was considerably enhanced upon the addition of chlorobutanol. Results of in vitro tests employing microorganisms commonly involved in local infections indicated that the two agents in combination act synergistically [1, 2].
Name dyclonine hydrochloride
Synonyms 1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (1:1)
1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride (1:1)
4-n-Butoxy-β-(1-piperidyl)propiophenone hydrochloride
Tanaclone
1-(2-(4-Butoxybenzoyl)ethyl)piperidine Hydrochloride
1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI)
MFCD00035386
4'-BUTOXY-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE
1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone Hydrochloride
4-n-Butoxy-b-(1-piperidyl)propiophenone Hydrochloride
1-Propanone, 1- (4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride
Dyclone
Dyclonine hydrochloride
EINECS 208-633-6
1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one,hydrochloride
1-(4-Butoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1)
Dyclocaine hydrochloride
dyclonine hcl
Piperidine, 1-[2-(4-butoxybenzoyl)ethyl], hydrochloride
Dyclothane
Dyclonine (hydrochloride)
Description Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.Target: Sodium ChannelDyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt. Dyclonine hydrochloride has been found to possess, in addition to its topical anesthetic properties, significant bactericidal and fungicidal activity. Self-sterilizing action manifested by preparations containing the drug was considerably enhanced upon the addition of chlorobutanol. Results of in vitro tests employing microorganisms commonly involved in local infections indicated that the two agents in combination act synergistically [1, 2].
Related Catalog
References

[1]. Florestano, H.J. and M.E. Bahler, Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc (Baltim), 1956. 45(5): p. 320-5.

[2]. Gargiulo, A.V., G.M. Burns, and C.P. Huck, Dyclonine hydrochloride--a topical agent for managing pain. Ill Dent J, 1992. 61(4): p. 303-4.
Boiling Point 424.5ºC at 760 mmHg
Melting Point 175-176°C
Molecular Formula C18H28ClNO2
Molecular Weight 325.873
Flash Point 210.5ºC
Exact Mass 325.180847
PSA 29.54000
LogP 4.66410

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UG8750000
CHEMICAL NAME :
Propiophenone, 4'-butoxy-3-piperidino-, hydrochloride
CAS REGISTRY NUMBER :
536-43-6
LAST UPDATED :
199504
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C18-H27-N-O2.Cl-H
MOLECULAR WEIGHT :
325.92
WISWESSER LINE NOTATION :
T6NTJ A2VR DO4 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,410,1962
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,410,1962
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,708,1958 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,708,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
201 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,413,1955
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,616,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,410,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
37 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,708,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Behavioral - muscle contraction or spasticity Behavioral - irritability
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,419,1955
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,616,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
9500 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,419,1955
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,616,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4641 No. of Facilities: 15 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 197 (estimated) No. of Female Employees: 136 (estimated)
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S26-S36
RIDADR 3249
WGK Germany 3
RTECS UG8750000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2942000000
50-00-0 structure

50-00-0

6091-44-7 structure

6091-44-7

5736-89-0 structure

5736-89-0

~%

536-43-6 structure

536-43-6

Literature: CHEMTECH, , vol. 4, p. 241,243 Journal of the American Pharmaceutical Association (1912-1977), , vol. 46, p. 542,544
Precursor  3

DownStream  0

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 536-43-6 | Chemsrc address: https://m.chemsrc.com/en/baike/833617.html

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