18474-59-4

18474-59-4 structure

Name: 6-Methyl-1H-indole-2-carboxylic acid
Chemical Name: 6-Methyl-1H-indole-2-carboxylic acid
CAS Number: 18474-59-4
Molecular Formula: C₁₀H₉NO₂
Molecular Weight: 175.184
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2018-07-21 16:15:12
Modify Date: 2024-01-02 22:33:14
eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex)[1].

Name	6-Methyl-1H-indole-2-carboxylic acid
Synonyms	1H-Indole-2-carboxylic acid, 6-methyl- 6-Methyl-1H-indole-2-carboxylic acid

Description	eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)
References	[1]. Ito M, et al. Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem. 2017 Apr 1;25(7):2200-2209.

Hazard Codes	Xi: Irritant;
HS Code	2933990090

95-81-8

127-17-3

18474-59-4

Literature: Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4511 - 4525

103264-29-5

18474-59-4

Literature: Gazzetta Chimica Italiana, , vol. 87, p. 949,953, 958

89-58-7

18474-59-4

Literature: Journal of the American Chemical Society, , vol. 70, p. 3787

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%