Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Flumazenil acid
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Purity: 98.0%
Stocking Period: 10 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Email: enquiry@dycnchem.com

84378-44-9

84378-44-9 structure

84378-44-9 structure

Name: Flumazenil acid
Chemical Name: 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
CAS Number: 84378-44-9
Molecular Formula: C₁₃H₁₀FN₃O₃
Molecular Weight: 275.24
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-12-29 21:11:20
Modify Date: 2025-08-25 14:58:45
Flumazenil acid is a metabolite of Flumazenil[1]. Flumazenil is a GABAA receptor antagonist[2].

Name	8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
Synonyms	Flumazenil acid 3-desmethylflumazenil 8-Fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid desethylflumazenyl desethylflumazenil Ro 15-3890

Description	Flumazenil acid is a metabolite of Flumazenil[1]. Flumazenil is a GABAA receptor antagonist[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. Kleingeist B, et al. Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase. J Pharm Pharm Sci. 1998 Jan-Apr;1(1):38-46. [2]. Mograbi KM, et al. Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice. Physiol Rep. 2017 Mar;5(6). pii: e13081.

Density	1.6±0.1 g/cm3
Boiling Point	570.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₀FN₃O₃
Molecular Weight	275.24
Flash Point	298.8±30.1 °C
Exact Mass	275.070618
PSA	75.43000
LogP	-0.16
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.697

RIDADR	NONH for all modes of transport

78755-81-4 structure

78755-81-4

~97%

84378-44-9 structure

84378-44-9

Literature: Jackson, Alexander; Guilbert, Benedicte B.; Plant, Stuart D.; Goggi, Julian; Battle, Mark R.; Woodcraft, John L.; Gaeta, Alessandra; Jones, Clare L.; Bouvet, Denis R.; Jones, Paul A.; O'Shea, Dennis M.; Zheng, Penny Hao; Brown, Samantha L.; Ewan, Amanda L.; Trigg, William Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 821 - 826

Precursor 1
78755-81-4
DownStream 1
133368-73-7

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