Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride
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122111-05-1

122111-05-1 structure

Name: 4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride
Chemical Name: 4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one,hydrochloride
CAS Number: 122111-05-1
Molecular Formula: C₉H₁₂ClF₂N₃O₄
Molecular Weight: 299.66
Catalog: Research Areas Cancer
Create Date: 2018-06-11 13:33:43
Modify Date: 2026-07-08 22:57:34
1'-epi Gemcitabine hydrochloride is the inactive isomer of Gemcitabine hydrochloride (HY-B0003), and can be used as an experimental control. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2].

Name	4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one,hydrochloride
Synonyms	Gemcitabine (alpha-Isomer) HCl Gemcitabine impurity 5/ 1’-i Gemcitabine Hydrochloride/Gemcitabine (alpha-Isomer) HCl/4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one,hydrochloride Gemcitabine Impurity B（Hydrochloride) 1’-i Gemcitabine Hydrochloride, min Gemcitabine Impurity 2(Gemcitabine Impurity B) GemcitabineImpurityB-13C-15N2HCl Gemcitabine Impurity 2 Hydrochloride (Gemcitabine Impurity B Hydrochloride) 1'-i Gemcitabine (hydrochloride) 2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-, hydrochloride (1:1) 4-amino-1-((2S,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride Gemcitabine α-anomer hydrogen chloride Gemcitabine Impurity B 2'-deoxy-2',2'-difluorocytidine hydrochloride Gemcitabine Impurity B HCl (Gemcitabine alpha-Isomer HCl) 4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-2(1H)-pyriMidinone Hydrochloride Gemcitabine (alpha-Isomer) Hydrochloride Gemcitabine Impurity B HCl Gemcitabine alpha isomer reference substance 4-Amino-1-(2-deoxy-2,2-difluoro-\|A-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride 1’-i Gemcitabine Hydrochloride 4-amino-1-((2S,4R,5R)-3,3 1'-Epi Gemcitabine Hydrochloride

Description	1'-epi Gemcitabine hydrochloride is the inactive isomer of Gemcitabine hydrochloride (HY-B0003), and can be used as an experimental control. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Yip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17;13:194. [2]. Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292(22):9136-9149. [3]. Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18(2):198-206 [4]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80

Molecular Formula	C₉H₁₂ClF₂N₃O₄
Molecular Weight	299.66
Exact Mass	299.04800
PSA	110.60000
LogP	0.09460

103882-84-4

122111-05-1

122111-03-9

Literature: DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC. Patent: WO2007/117760 A2, 2007 ; Location in patent: Page/Page column 21 ;

14631-20-0

134877-42-2

122111-05-1

122111-03-9

Literature: POLTURI, Ramesh, Babu; VENKATA, Subramanian, Hariharakrishnan; BETINI, Ramesh Patent: WO2005/95430 A1, 2005 ; Location in patent: Page/Page column 18-20 ;

Precursor 3
103882-84-4 14631-20-0 134877-42-2
DownStream 0

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