122111-05-1

• 常用中文名：吉西他滨ALFA异构体盐酸盐
• 常用英文名：4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride
• CAS号：122111-05-1
• 分子式：C₉H₁₂ClF₂N₃O₄
• 分子量：299.66
• 相关类别： 研究领域 癌症
• 发布时间：2018-06-11 13:33:43
• 更新时间：2026-07-08 22:57:34
• 1'-epi Gemcitabine hydrochloride 是 Gemcitabine hydrochloride (HY-B0003) 的非活性异构体,可作为实验中的对照化合物。Gemcitabine Hydrochloride (LY 188011 Hydrochloride) 是一种嘧啶核苷类似物抗代谢药 (nucleoside antimetabolite/analog) 和抗肿瘤剂。Gemcitabine 抑制 DNA 合成 (DNA synthesis) 和修复,导致细胞自噬 (autophagy) 和凋亡 (apoptosis)。

名称

• 中文名: 吉西他滨ALFA异构体盐酸盐
• 英文名: 4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one,hydrochloride
• 中文别名: 吉西他滨(Α-异构体)HCL; 吉西他滨杂质B HCL(吉西他滨Α异构体HCL); 吉西他滨杂质2 盐酸盐 (吉西他滨杂质B 盐酸盐); 盐酸吉西他滨(Α异构体); 吉西他滨Α异构体盐酸盐; 吉西他滨杂质2(吉西他滨杂质B); 吉西他滨杂质B; ALPHA-吉西他滨; 吉西他滨α异构体对照品; 吉西他滨杂质B HCL(吉西他滨Α-异构体HCL); Α-吉西他滨; 4-氨基-1-(2-脱氧-2,2-二氟呋喃戊糖基)-2(1H)-嘧啶酮盐酸盐(1:1); 4-氨基-1-((2S,4R,5R)-3,3-二氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2(1H)-酮盐酸盐; 吉西他滨Α异构体对照品; 盐酸吉西他滨杂质B; 盐酸吉西他滨异构体; 吉西他滨杂质B盐酸盐; 吉西他滨杂质B HCL; 吉西他滨 杂质 B 盐酸盐(吉西他滨 Α-异构体盐酸盐); 吉西他滨(α-异构体)HCl; 1'-吉西他滨异构体盐酸盐; 吉西他滨杂质B 吉西他滨ALFA异构体盐酸盐
• 英文别名: Gemcitabine (alpha-Isomer) HCl; Gemcitabine impurity 5/ 1’-i Gemcitabine Hydrochloride/Gemcitabine (alpha-Isomer) HCl/4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one,hydrochloride; Gemcitabine Impurity B（Hydrochloride); 1’-i Gemcitabine Hydrochloride, min; Gemcitabine Impurity 2(Gemcitabine Impurity B); GemcitabineImpurityB-13C-15N2HCl; Gemcitabine Impurity 2 Hydrochloride (Gemcitabine Impurity B Hydrochloride); 1'-i Gemcitabine (hydrochloride); 2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-, hydrochloride (1:1); 4-amino-1-((2S,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride; Gemcitabine α-anomer hydrogen chloride; Gemcitabine Impurity B; 2'-deoxy-2',2'-difluorocytidine hydrochloride; Gemcitabine Impurity B HCl (Gemcitabine alpha-Isomer HCl); 4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-2(1H)-pyriMidinone Hydrochloride; Gemcitabine (alpha-Isomer) Hydrochloride; Gemcitabine Impurity B HCl; Gemcitabine alpha isomer reference substance; 4-Amino-1-(2-deoxy-2,2-difluoro-|A-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride; 1’-i Gemcitabine Hydrochloride; 4-amino-1-((2S,4R,5R)-3,3; 1'-Epi Gemcitabine Hydrochloride

物化性质

• 分子式: C₉H₁₂ClF₂N₃O₄
• 分子量: 299.66
• 精确质量: 299.04800
• PSA: 110.60000
• LogP: 0.09460

生物活性

• 描述: 1'-epi Gemcitabine hydrochloride 是 Gemcitabine hydrochloride (HY-B0003) 的非活性异构体,可作为实验中的对照化合物。Gemcitabine Hydrochloride (LY 188011 Hydrochloride) 是一种嘧啶核苷类似物抗代谢药 (nucleoside antimetabolite/analog) 和抗肿瘤剂。Gemcitabine 抑制 DNA 合成 (DNA synthesis) 和修复,导致细胞自噬 (autophagy) 和凋亡 (apoptosis)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Yip-Schneider MT, et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17;13:194.

  [2]. Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292(22):9136-9149.

  [3]. Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18(2):198-206

  [4]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80

合成路线

103882-84-4 ~% 122111-05-1 122111-03-9

文献：DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC. Patent: WO2007/117760 A2, 2007 ; Location in patent: Page/Page column 21 ;

14631-20-0 134877-42-2 ~% 122111-05-1 122111-03-9

文献：POLTURI, Ramesh, Babu; VENKATA, Subramanian, Hariharakrishnan; BETINI, Ramesh Patent: WO2005/95430 A1, 2005 ; Location in patent: Page/Page column 18-20 ;

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