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Product Name: HOPan
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18679-90-8

18679-90-8 structure

18679-90-8 structure

Name: HOPan
Chemical Name: 4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid
CAS Number: 18679-90-8
Molecular Formula: C₁₀H₁₉NO₅
Molecular Weight: 233.26
Catalog: Research Areas Infection
Create Date: 2018-06-27 10:26:45
Modify Date: 2024-01-03 10:45:28
HoPan inhibits phosphopantotenoylcysteine synthetase activity.

Name	4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid
Synonyms	hopantenic acid HOPA Homopantothenic acid 4-D-pantoylamino-butyric acid D-Homopantothenic acid Hopantenic 4-D-Pantoylamino-buttersaeure HOPan

Description	HoPan inhibits phosphopantotenoylcysteine synthetase activity.
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Mostert KJ, et al. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS Chem Biol. 2021 Nov 19;16(11):2401-2414.

Density	1.23g/cm3
Boiling Point	556ºC at 760mmHg
Molecular Formula	C₁₀H₁₉NO₅
Molecular Weight	233.26
Flash Point	290.1ºC
Exact Mass	233.12600
PSA	106.86000
Vapour Pressure	1.11E-14mmHg at 25°C
Index of Refraction	1.508

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES9570000

CHEMICAL NAME :: Butyric acid, 4-(2,4-dihydroxy-3,3-dimethylbutyramido)-, D-(+)-

CAS REGISTRY NUMBER :: 18679-90-8

LAST UPDATED :: 198511

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H19-N-O5

MOLECULAR WEIGHT :: 233.30

WISWESSER LINE NOTATION :: QV3MVYQX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,546,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962

HS Code	2924199090

599-04-2 structure

599-04-2

56-12-2 structure

56-12-2

~96%

18679-90-8 structure

18679-90-8

Literature: Van Wyk, Marianne; Strauss, Erick Organic and Biomolecular Chemistry, 2008 , vol. 6, # 23 p. 4348 - 4355

Precursor 2
599-04-2 56-12-2
DownStream 0

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%