26246-41-3

26246-41-3 structure

Name: Reticulol
Chemical Name: 6,8-dihydroxy-7-methoxy-3-methylisochromen-1-one
CAS Number: 26246-41-3
Molecular Formula: C₁₁H₁₀O₅
Molecular Weight: 222.19
Create Date: 2017-10-25 23:55:21
Modify Date: 2024-01-13 19:24:04
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].

Name	6,8-dihydroxy-7-methoxy-3-methylisochromen-1-one
Synonyms	6,8-dihydroxy-7-methoxy-3-methyl-isochromen-1-one Reticulol 6,8-Dihydroxy-7-methoxy-3-methylisocumarin

Description	Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
In Vitro	Reticulol (25-200 μM) 对人肺肿瘤细胞系 A427 和小鼠黑色素瘤细胞系 B16F10 显示出有效的细胞毒性[1]。
In Vivo	Reticulol (10 mg/kg，50 mg/kg；静脉注射；肿瘤植入后第 3 天和第 5 天) 抑制 B16F10 黑色素瘤小鼠的肿瘤生长，并显示肺转移阻断作用[1]。 Animal Model: Pathogen-free female C57BL/6J mice[1] Dosage: 10 mg/kg, 50 mg/kg Administration: IV via the tail vein; day 3 and day 5 after tumor implanted Result: Inhibited tumor growth.
References	[1]. Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60. [2]. Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53.

HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%