Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)-
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Purity: 98.0%
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10245-81-5

10245-81-5 structure

Name: Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)-
Chemical Name: 2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol
CAS Number: 10245-81-5
Molecular Formula: C₁₀H₄Br₅NO
Molecular Weight: 553.66
Create Date: 2016-09-27 13:01:53
Modify Date: 2024-01-10 09:53:17
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1].

Name	2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol
Synonyms	2,4-dibromo-6-(3,4,5-tribromo-pyrrol-2-yl)-phenol Phenol,2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl) pentabromopseulidin 2,3,4-tribromo-5-(1'-hydroxy-2',4'-dibromophenyl)-pyrrole PBQ Pentabromopseudilin

Description	Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1].
Related Catalog	Research Areas >> Cancer
In Vitro	Pentabromopseudilin (PBrP) (0.01-1 μM, 6 h) 可防止 TGF-β 诱导的 Smad 蛋白磷酸化和核转位[1]。 PBrP (0.5 μM, 6 h) 抑制 TGF-β 刺激的转录反应[1]。 PBrP (0-1 μM, 6 h) 抑制 A549 细胞中 TGF-β 诱导的 EMT[1]。 PBrP (0.2 μM, 20 h) 抑制 TGF-β 诱导的细胞迁移[1]。 PBrP (0.01-1⟩μM, 6 h) 通过增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。 PBrP (0.5μM, 0, 1, 3 h) 通过细胞膜穴样内陷增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。 Western Blot Analysis[1] Cell Line: Mv1Lu, A549, Clone 9 and HepG2 cells Concentration: 0.01-1 μM (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5 μM (Mv1Lu, A549 and HepG2 cells) Incubation Time: 6 h (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5, 1, 2, 4, 6 h (Mv1Lu, A549 and HepG2 cells) Result: Suppressed the TGF-β-stimulated Smad2/3 phosphorylation in a dose-dependent manner in these cell lines. Prevented TGF-β induced the nuclear translocation of Smad2/3 and PBrP alone did not alter the localisation of Smad proteins. Immunofluorescence[1] Cell Line: A549 cells Concentration: 0.2 μM Incubation Time: 6 h Result: Abolished TGF-β-induced Smad2/3 nuclear translocation. Cell Migration Assay [1] Cell Line: A549 cells Concentration: 0.2 μM Incubation Time: 20 h Result: Suppressed TGF-β-stimulated cell migration and did not close the wound.
References	[1]. Shih-Wei W, et al. Pentabromopseudilin: a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation. J Enzyme Inhib Med Chem. 2018;33(1):920-935.

Density	2.606g/cm3
Boiling Point	464.2ºC at 760 mmHg
Molecular Formula	C₁₀H₄Br₅NO
Molecular Weight	553.66
Flash Point	234.5ºC
Exact Mass	548.62100
PSA	36.02000
LogP	6.19980
Vapour Pressure	3.07E-09mmHg at 25°C
Index of Refraction	1.739

HS Code	2933990090

Precursor 9
42041-50-9 856438-58-9 5896-17-3 13130-23-9
15790-59-7 61657-65-6 121789-25-1 121789-23-9
10245-82-6
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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