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  • DC Chemicals Limited
  • China
  • Product Name: EUK-134
  • Price: $600.0/100mg $950.0/250mg $1700.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


81065-76-1

81065-76-1 structure
81065-76-1 structure
  • Name: EUK-134
  • Chemical Name: manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride
  • CAS Number: 81065-76-1
  • Molecular Formula: C18H18ClMnN2O4
  • Molecular Weight: 416.738
  • Catalog: Biochemical Inhibitor Neuronal Signaling Beta Amyloid inhibitor
  • Create Date: 2018-10-20 04:52:55
  • Modify Date: 2024-01-02 13:47:50
  • EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3].

Name manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride
Synonyms Phenol, 2,2'-[1,2-ethanediylbis[nitrilo(E)methylidyne]]bis[6-methoxy-, manganese(3+) salt, hydrochloride (1:1:1)
ethylbisiminomethylguaiacol manganese chloride
Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}bis(6-methoxyphenolate) (1:1:1)
I14-7464
EUK-134
Description EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3].
Related Catalog
Target

NF-κB

In Vitro EUK-134 (10-300 μM) is able to improve cell viability and reduces Paraquat (1 mM)-induced cell death significantly via dismutation or scavenging of superoxide anions and reduces hydroxyl radical generation[2]. Higher concentrations of EUK-134 alone (30-300 μM) produces modest but significant reductions in cellular viability; however, this effect is not reflected in cell death measurements made at these concentrations[2]. EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity.Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.EUK-134 is a mitoprotective antioxidant with Mn-superoxide dismutase (Mn SOD) and catalase activity[3]. Cell Viability Assay[2] Cell Line: NRK-52E cells Concentration: 0, 1, 3, 10, 30, 100, and 300 μM Incubation Time: 24 hours Result: Co-incubation with Paraquat (1 mM) and increasing concentrations of EUK-134 (1-300 μM) resulted in a significant reduction in paraquat-induced cellular injury and death at 100 and 300 μM.
References

[1]. P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62(11):1664-6.

[2]. Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43(4):528-34.

[3]. Sreeja Purushothaman, et al. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420(1-2):185-94.

Molecular Formula C18H18ClMnN2O4
Molecular Weight 416.738
Exact Mass 416.033569
PSA 58.62000
LogP 3.09010
Appearance , faint to very dark brown
Storage condition ?20°C
Water Solubility H2O: soluble2mg/mL, clear (warmed)
RIDADR NONH for all modes of transport