810668-37-2

810668-37-2 structure

Name: Resolvin D2
Chemical Name: Resolvin D2
CAS Number: 810668-37-2
Molecular Formula: C₂₂H₃₂O₅
Molecular Weight: 376.487
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2017-10-01 07:43:00
Modify Date: 2024-01-02 16:25:25
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

Name	Resolvin D2
Synonyms	Resolvin D2 4,8,10,12,14,19-Docosahexaenoic acid, 7,16,17-trihydroxy-, (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)- (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)-7,16,17-Trihydroxy-4,8,10,12,14,19-docosahexaenoic acid

Description	Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	TRP Channel[3]
In Vivo	Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions[1]. Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression[2]. Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain[3]. Animal Model: Adult CD1 mice (male, 8–10 weeks)[3] Dosage: 10 ng Administration: Intraplantar administration Result: Inhibited inflammatory pain.
References	[1]. Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307. [2]. Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461(7268):1287-91. [3]. Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31(50):18433-8.

Density	1.1±0.1 g/cm3
Boiling Point	609.2±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₂O₅
Molecular Weight	376.487
Flash Point	336.3±28.0 °C
Exact Mass	376.224976
PSA	97.99000
LogP	2.70
Vapour Pressure	0.0±4.0 mmHg at 25°C
Index of Refraction	1.559

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