872726-44-8

872726-44-8 structure

Name: NSC 721648
Chemical Name: 2-(3,4-dimethoxyphenyl)-5-fluoro-1,3-benzothiazole
CAS Number: 872726-44-8
Molecular Formula: C₁₅H₁₂FNO₂S
Molecular Weight: 289.325
Catalog: Research Areas Cancer
Create Date: 2016-07-19 01:43:30
Modify Date: 2024-01-10 09:36:03
GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines[1][2][3].

Name	2-(3,4-dimethoxyphenyl)-5-fluoro-1,3-benzothiazole
Synonyms	unii-x3xwa9lq3q 2-(3,4-Dimethoxyphenyl)-5-fluoro-1,3-benzothiazole gw 610 Benzothiazole, 2-(3,4-dimethoxyphenyl)-5-fluoro-

Description	GW 610 (NSC 721648), an antitumor agent, shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	GW 610 inhibits the proliferation of MCF-7, MDA 468, KM 12, and HCC 2998 cells, with GI50s of <0.1 nM, <0.1 nM, 290 nM, and 0.25 nM, respectively[1]. GW 610 (0.1-1 μM) induces CYP1A1 mRNA and protein in MDA-MB-468, MCF-7, KM12, and HCC2998 cells, whereas CYP2S1 and CYP2W1 are induced only in breast cancer cells[3]. Western Blot Analysis[3] Cell Line: MDA-MB-468, MCF-7, KM12, and HCC2998 cells Concentration: 0.1, 1 μM Incubation Time: 48 hours Result: Induced CYP1A1 mRNA and protein in all cell lines including KM12 and HCC2998 CRC cells. Induced CYP2S1 and CYP2W1 mRNA and protein expression in MDA-MB-468 and MCF-7 breast cancer cells.
References	[1]. Mortimer CG, et, al. Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem. 2006 Jan 12;49(1):179-85. [2]. Aiello S, et, al. Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). J Med Chem. 2008 Aug 28;51(16):5135-9. [3]. Tan BS, et, al. CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Mol Cancer Ther. 2011 Oct;10(10):1982-92.

Density	1.3±0.1 g/cm3
Boiling Point	422.8±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₂FNO₂S
Molecular Weight	289.325
Flash Point	209.5±31.5 °C
Exact Mass	289.057281
PSA	59.59000
LogP	4.70
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.619

120-14-9

224791-45-1

~90%

872726-44-8

Literature: Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607

1424343-82-7

~65%

872726-44-8

Literature: Prasad; Sekar Organic and Biomolecular Chemistry, 2013 , vol. 11, # 10 p. 1659 - 1665

20358-07-0

872726-44-8

Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8599 - 8607

458-05-9

872726-44-8

Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8599 - 8607

372-19-0

872726-44-8

Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8599 - 8607

Precursor 5
120-14-9 224791-45-1 20358-07-0 372-19-0
458-05-9
DownStream 0

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