1294048-82-0

1294048-82-0 structure

Name: Thiamethoxam-d3
Chemical Name: (NZ)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-(trideuteriomethyl)-1,3,5-oxadiazinan-4-ylidene]nitramide
CAS Number: 1294048-82-0
Molecular Formula: C₈H₇ClD₃N₅O₃S
Molecular Weight: 294.733
Catalog: Research Areas Others
Create Date: 2018-02-13 08:00:00
Modify Date: 2024-01-09 00:44:05
Thiamethoxam-d3 is the deuterium labeled Thiamethoxam[1]. Thiamethoxam is a broad spectrum neonicotinoid insecticide[2][3].

Name	(NZ)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-(trideuteriomethyl)-1,3,5-oxadiazinan-4-ylidene]nitramide
Synonyms	Thiamethoxam-d3 (4Z)-3-[(2-Chloro-1,3-thiazol-5-yl)methyl]-5-(H)methyl-N-nitro-1,3,5-oxadiazinan-4-imine 3-(2-Chloro-5-thiazolylmethyl)tetrahydro-5-methyl-d3-N-nitro-4H-1,3,5-oxadiazin-4-imine 4H-1,3,5-Oxadiazin-4-imine, 3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-(methyl-d)-N-nitro-, (4Z)-

Description	Thiamethoxam-d3 is the deuterium labeled Thiamethoxam[1]. Thiamethoxam is a broad spectrum neonicotinoid insecticide[2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lobson C, et al. Fate of thiamethoxam in mesocosms and response of the zooplankton community. Sci Total Environ. 2018 Oct 1;637-638:1150-1157. [3]. Ludicke JC, et al. Thiamethoxam impairs honey bee visual learning, alters decision times, and increases abnormal behaviors. Ecotoxicol Environ Saf. 2020 Apr 15193:110367.