1216739-35-3

1216739-35-3 structure
1216739-35-3 structure
  • Name: Bumetanide D5
  • Chemical Name: 3-(butylamino)-4-(2,3,4,5,6-pentadeuteriophenoxy)-5-sulfamoylbenzoic acid
  • CAS Number: 1216739-35-3
  • Molecular Formula: C17H15D5N2O5S
  • Molecular Weight: 369.44700
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel NKCC
  • Create Date: 2017-09-26 14:31:28
  • Modify Date: 2024-01-03 18:24:59
  • Bumetanide D5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with  IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

Name 3-(butylamino)-4-(2,3,4,5,6-pentadeuteriophenoxy)-5-sulfamoylbenzoic acid
Synonyms Fordiuran-d5
[2H5]-Bumetanide
Bumex-d5
Bufenox-d5
Burinex-d5
PF 1593-d5
Lunetoron-d5
Lixil-d5
Bumetanide-d5
Description Bumetanide D5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with  IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].
Related Catalog
References

[1]. Sandström PE1, et al. Evidence for diabetogenic action of bumetanide in mice.Eur J Pharmacol. 1988 May 20;150(1-2):35-41.

Melting Point 234-236 °C
Molecular Formula C17H15D5N2O5S
Molecular Weight 369.44700
Exact Mass 369.14100
PSA 127.10000
LogP 4.89060
Hazard Codes Xi