59090-48-1
59090-48-1 structure
- Name: Thymidine, a-azido- (9CI)
- Chemical Name: 5-(azidomethyl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- CAS Number: 59090-48-1
- Molecular Formula: C10H13N5O5
- Molecular Weight: 283.24
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
- Create Date: 2017-08-20 20:09:09
- Modify Date: 2024-01-09 14:10:46
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α-Azidothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
| Name | 5-(azidomethyl)-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
|---|---|
| Synonyms |
5-azido-2'-O-deoxythymidine
5-azidomethyl-2'-deoxyuridine |
| Description | α-Azidothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C10H13N5O5 |
|---|---|
| Molecular Weight | 283.24 |
| Exact Mass | 283.09200 |
| PSA | 154.30000 |
|
~85%
59090-48-1 |
| Literature: Xu, Xiaowei; Yan, Shengyong; Hu, Jianlin; Guo, Pu; Wei, Lai; Weng, Xiaocheng; Zhou, Xiang Tetrahedron, 2013 , vol. 69, # 46 p. 9870 - 9874 |
|
~92%
59090-48-1 |
| Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491 |
|
~%
59090-48-1 |
| Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491 |
|
~%
59090-48-1 |
| Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491 |
|
~%
59090-48-1 |
| Literature: Hong, In Seok; Ding, Hui; Greenberg, Marc M. Journal of the American Chemical Society, 2006 , vol. 128, # 2 p. 485 - 491 |
|
~%
59090-48-1 |
| Literature: Shiau, George T.; Schinazi, Raymond F.; Chen, Ming S.; Prusoff, William H. Journal of Medicinal Chemistry, 1980 , vol. 23, # 2 p. 127 - 133 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |