155584-74-0
155584-74-0 structure
- Name: VUF 10166
- Chemical Name: 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline
- CAS Number: 155584-74-0
- Molecular Formula: C13H15ClN4
- Molecular Weight: 262.738
- Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Antagonist
- Create Date: 2018-10-20 18:29:54
- Modify Date: 2024-01-02 10:44:01
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VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1].
| Name | 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline |
|---|---|
| Synonyms |
Quinoxaline, 2-chloro-3-(4-methyl-1-piperazinyl)-
Quinoxaline (2-chloro-3-(4-methyl-1-piperazinyl) 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline VUF 10166 |
| Description | VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1]. |
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| Related Catalog | |
| Target |
5-HT3A Receptor:0.04 nM (Ki) 5-HT 3 AB:22 nM (Ki) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 389.6±42.0 °C at 760 mmHg |
| Molecular Formula | C13H15ClN4 |
| Molecular Weight | 262.738 |
| Flash Point | 189.4±27.9 °C |
| Exact Mass | 262.098511 |
| PSA | 32.26000 |
| LogP | 2.79 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.637 |
| Storage condition | -20°C |
| HS Code | 2933990090 |
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| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |