Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sulphamoprine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

155-91-9

155-91-9 structure

Name: Sulphamoprine
Chemical Name: 4-amino-N-(4,6-dimethoxypyrimidin-2-yl)benzenesulfonamide
CAS Number: 155-91-9
Molecular Formula: C₁₂H₁₄N₄O₄S
Molecular Weight: 310.329
Create Date: 2018-03-26 08:00:00
Modify Date: 2024-01-03 23:10:50

Name	4-amino-N-(4,6-dimethoxypyrimidin-2-yl)benzenesulfonamide
Synonyms	Sulfanilsaeure-(4,6-dimethoxy-pyrimidin-2-ylamid) Sulphamoprine Sulfadimethoxypyrimidine 2-p-Aminobenzenesulfonamido-4,6-dimethoxypyrimidine sulphadimethoxine sulfadimethoxine 4-Amino-N-(4,6-dimethoxy-2-pyrimidinyl)benzenesulfonamide Benzenesulfonamide, 4-amino-N-(4,6-dimethoxy-2-pyrimidinyl)- SDmP sulfanilic acid-(4,6-dimethoxy-pyrimidin-2-ylamide) 6-(p-aminobenzenesulphonamido)-2,4-dimethoxypyrimidine 4-Amino-N-(4,6-dimethoxypyrimidin-2-yl)benzenesulfonamide Sulfamoprine ICI 3435 Sulphadimethoxypyrimidine 4-amino-N-(4,6-dimethoxy-pyrimidin-2-yl)-benzenesulfonamide

Density	1.4±0.1 g/cm3
Boiling Point	570.7±60.0 °C at 760 mmHg
Melting Point	200ºC
Molecular Formula	C₁₂H₁₄N₄O₄S
Molecular Weight	310.329
Flash Point	298.9±32.9 °C
Exact Mass	310.073578
PSA	124.81000
LogP	1.41
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.623

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9495000

CHEMICAL NAME :: Benzenesulfonamide, 4-amino-N-(4,6-dimethoxy-2-pyrimidinyl)-

CAS REGISTRY NUMBER :: 155-91-9

BEILSTEIN REFERENCE NO. :: 0307123

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H14-N4-O4-S

MOLECULAR WEIGHT :: 310.36

WISWESSER LINE NOTATION :: T6N CNJ BMSWR DZ& DO1 FO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 gm/kg/28D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Blood - normocytic anemia Related to Chronic Data - death

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 2,149,1947 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 538 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - physical

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - stillbirth

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 825 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 11-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - skin and skin appendages

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 21,151,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2520 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2520 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,305,1964

Hazard Codes	Xi
Risk Phrases	36/37/38-43
Safety Phrases	26-36/37-24/25-23
HS Code	2935009090

24341-30-8

155-91-9

Literature: Rose; Tuey Journal of the Chemical Society, 1946 , p. 81,84 Full Text Show Details Braker et al. Journal of the American Chemical Society, 1947 , vol. 69, p. 3072,3075 Full Text Show Details Leitch et al. Canadian Journal of Research, Section B: Chemical Sciences, 1947 , vol. 25, p. 14,17

121-60-8

155-91-9

Literature: Leitch et al. Canadian Journal of Research, Section B: Chemical Sciences, 1947 , vol. 25, p. 14,17

Precursor 2
24341-30-8 121-60-8
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4