41060-15-5
41060-15-5 structure
- Name: Neobavaisoflavone
- Chemical Name: 7-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one
- CAS Number: 41060-15-5
- Molecular Formula: C20H18O4
- Molecular Weight: 322.354
- Catalog: Natural product Flavonoids
- Create Date: 2018-09-18 09:39:45
- Modify Date: 2026-07-05 22:41:37
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Neobavaisoflavone, an isoflavone isolated from Psoralea corylifolia, has striking anti-inflammatory and anti-cancer effects. IC50 value: 42.93 μM (toward CCRF-CEM cells); 114.64 μM [against HCT116 (p53(+/+)) cells] [2]Target:In vitro: In the cancer cells, neobavaisoflavone sensitizes human U373MG glioma cells to TRAIL-mediated apoptosis; upregulated DR5 expression; induced TRAIL-mediated apoptosis in human glioma cells by suppressing migration and invasion, and by inhibiting anoikis resistance [1]. In caner cell lines, neobavaisoflavone is selectively active, and IC50 values below 115 μM were obtained on 6/9 cell lines, with values ranging from 42.93 μM (toward CCRF-CEM cells) to 114.64 μM [against HCT116 (p53(+/+)) cells] [2]. In vivo:
| Name | 7-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one |
|---|---|
| Synonyms |
7-Hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-1-benzopyran-4-one
7-Hydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-4H-chromen-4-one 7-Hydroxy-3-(4-hydroxy-3-(3-methylbut-2-enyl)phenyl)-4H-chromen-4-one 4H-1-Benzopyran-4-one, 7-hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl] 3''-PRENYLDAIDZEIN flavonoid,corylifolia,Neobavaisoflavone,anti-oxidation,polymerase,Apoptosis,anti-cancer,DNA/RNA Synthesis,Inhibitor,Psoralea,agegation,inhibit,platelet,DNA,anti-inflammatory Neobavaisoflavone-RM 7-Hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-chromen-4-one neobavaisoflavone Neobavaisoavone Neobavaisoflavone(AS) Neobavaisoflavone, 10 mM in DMSO Neobavaisoflavone from Psoralea corylifolia L 4',7-Dihydroxy-3'-(3-methyl-2-butenyl)isoflavone |
| Description | Neobavaisoflavone, an isoflavone isolated from Psoralea corylifolia, has striking anti-inflammatory and anti-cancer effects. IC50 value: 42.93 μM (toward CCRF-CEM cells); 114.64 μM [against HCT116 (p53(+/+)) cells] [2]Target:In vitro: In the cancer cells, neobavaisoflavone sensitizes human U373MG glioma cells to TRAIL-mediated apoptosis; upregulated DR5 expression; induced TRAIL-mediated apoptosis in human glioma cells by suppressing migration and invasion, and by inhibiting anoikis resistance [1]. In caner cell lines, neobavaisoflavone is selectively active, and IC50 values below 115 μM were obtained on 6/9 cell lines, with values ranging from 42.93 μM (toward CCRF-CEM cells) to 114.64 μM [against HCT116 (p53(+/+)) cells] [2]. In vivo: |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 545.0±50.0 °C at 760 mmHg |
| Melting Point | 195-196ºC |
| Molecular Formula | C20H18O4 |
| Molecular Weight | 322.354 |
| Flash Point | 197.7±23.6 °C |
| Exact Mass | 322.120514 |
| PSA | 70.67000 |
| LogP | 4.87 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.645 |
| RIDADR | NONH for all modes of transport |
|---|---|
| RTECS | DJ3100028 |