- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Neuropeptide VF (124-131) (human) trifluoroacetate salt
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Neuropeptide VF (124-131) (human)
- Price: $Inquiry/1kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- DC Chemicals Limited
- China
- Product Name: RFRP-3(human)
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: H-VAL-PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: NEUROPEPTIDE VF (124-131) (HUMAN)
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
311309-27-0
311309-27-0 structure
- Name: Neuropeptide VF (124-131) (human) trifluoroacetate salt
- Chemical Name: h-val-pro-asn-leu-pro-gln-arg-phe-nh2
- CAS Number: 311309-27-0
- Molecular Formula: C45H72N14O10
- Molecular Weight: 969.14100
- Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
- Create Date: 2018-12-25 12:52:42
- Modify Date: 2024-01-14 11:30:08
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RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].
| Name | h-val-pro-asn-leu-pro-gln-arg-phe-nh2 |
|---|---|
| Synonyms |
RFRP-3 human trifluoroacetate salt
H2N-VPNLPQRF-AMIDE V-8-F-NH2,NPVF NPVF V-8-F-NH2 Neuropeptide VF (124-131) (human) |
| Description | RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1]. |
|---|---|
| Related Catalog | |
| In Vitro | RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1]. Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively. RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1]. RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1]. |
| References |
| Molecular Formula | C45H72N14O10 |
|---|---|
| Molecular Weight | 969.14100 |
| Exact Mass | 968.55600 |
| PSA | 403.31000 |
| LogP | 2.37640 |
| Hazard Codes | Xi |
|---|