- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: Dermorphin
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
77614-16-5
77614-16-5 structure
- Name: Dermorphin
- Chemical Name: (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
- CAS Number: 77614-16-5
- Molecular Formula: C40H50N8O10
- Molecular Weight: 802.87300
- Catalog: Peptides
- Create Date: 2017-04-28 22:51:50
- Modify Date: 2024-01-09 22:29:40
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Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin.
| Name | (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide |
|---|---|
| Synonyms |
Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide
Dermorphin H-Tyr-D-ala-phe-gly-tyr-pro-ser-NH2 |
| Description | Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. |
|---|---|
| Related Catalog | |
| Target |
μ-opioid receptor (MOR)[1] |
| In Vitro | Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2]. |
| Kinase Assay | Membrane protein (40 μg) is incubated in 0.5 mL volume of 50 mM Tris, 0.2 mM EGTA, 1 mM MgCl2, 100 mM NaCl, 0.1% BSA, 0.15 mM bacitracin; pH 7.4, GDP (33 μM), and ∼150 pM GTPγ[35S]. Varying concentrations of reference ligands (Dermorphin, N/OFQ, Dynorphin-A and Leu-enkephalin) or DeNo (1 pM-10 μM) is added prior to incubation. Non-specific binding is determined in the presence of unlabeled GTPγS (10 μM). Samples are incubated at 30°C for 1 h with gentle agitation. Reactions are terminated by vacuum filtration through dry Whatman GF/B filters, using a Brandel harvester[2]. |
| References |
| Molecular Formula | C40H50N8O10 |
|---|---|
| Molecular Weight | 802.87300 |
| Exact Mass | 802.36500 |
| PSA | 314.05000 |
| LogP | 3.98630 |
| Storage condition | 2-8℃ |