329897-62-3

329897-62-3 structure

Name: PHF6 trifluoroacetate salt
Chemical Name: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoic acid
CAS Number: 329897-62-3
Molecular Formula: C₃₆H₆₀N₈O₉
Molecular Weight: 748.91
Catalog: Research Areas Neurological Disease
Create Date: 2016-01-05 07:17:07
Modify Date: 2024-01-12 20:19:36
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1].

Name	(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoic acid
Synonyms	L-Lysine,L-valyl-L-glutaminyl-L-isoleucyl-L-valyl-L-tyrosyl PHF6 trifluoroacetate salt

Description	PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Aggregated tau-PHF6 (VQIVYK) potentiates NLRP3 inflammasome expression and autophagy in human microglial cells[1].
References	[1]. Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10(7):1652.