PHF6 trifluoroacetate salt

Modify Date: 2024-01-12 20:19:36

PHF6 trifluoroacetate salt Structure
PHF6 trifluoroacetate salt structure
Common Name PHF6 trifluoroacetate salt
CAS Number 329897-62-3 Molecular Weight 748.91
Density N/A Boiling Point N/A
Molecular Formula C36H60N8O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PHF6 trifluoroacetate salt


PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1].

 Names

Name (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoic acid
Synonym More Synonyms

 PHF6 trifluoroacetate salt Biological Activity

Description PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1].
Related Catalog
In Vitro Aggregated tau-PHF6 (VQIVYK) potentiates NLRP3 inflammasome expression and autophagy in human microglial cells[1].
References

[1]. Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10(7):1652.  

 Chemical & Physical Properties

Molecular Formula C36H60N8O9
Molecular Weight 748.91
Exact Mass 748.44800
PSA 316.60000
LogP 6.27500

 Synonyms

L-Lysine,L-valyl-L-glutaminyl-L-isoleucyl-L-valyl-L-tyrosyl
PHF6 trifluoroacetate salt