1216941-48-8

1216941-48-8 structure

Name: paritaprevir
Chemical Name: paritaprevir
CAS Number: 1216941-48-8
Molecular Formula: C₄₀H₄₃N₇O₇S
Molecular Weight: 765.87700
Catalog: Signaling Pathways Anti-infection HCV
Create Date: 2017-10-03 14:34:07
Modify Date: 2025-08-24 16:02:57
Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively.

Name	paritaprevir
Synonyms	(2R,6S,12Z,13aS,14aR,16aS)-N-(Cyclopropylsulfonyl)-6-(5-methylpyrazin-2-carboxamido)-5,16-dioxo-2-(phenanthridin-6-yloxy)-1,2,3,6,7,8,9,10,11,13a,14,15,16,16atetradecahydrocyclopropa(E)pyrrolo(1,2-a)(1,4)diazacyclopentadecine-14a(5H)-carboxamide Veruprevir anhydrous ABT450

Description	Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively.
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Inflammation/Immunology
Target	EC50: 1 nM(HCV 1a), 0.21 nM(HCV 1b)[1]
In Vitro	Paritaprevir demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50 range, 0.09 to 19 nM), with an EC50 of 0.09 nM against GT4a[2].
In Vivo	The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections1[1].
References	[1]. Smith MA,et al. Profile of?paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection. Drug Des Devel Ther.?2015 Nov 13;9:6083-94.? [2]. Schnell G, et al. Hepatitis C Virus Genotype 4 Resistance and Subtype Demographic Characterization of Patients Treated with Ombitasvir plus Paritaprevir/ritonavir. Antimicrob Agents Chemother. 2015 Aug 17. pii: AAC.01229-15.