210345-04-3
210345-04-3 structure
- Name: Z-LEHD-FMK
- Chemical Name: Z-Leu-Glu(OMe)-His-Asp(OMe) fluoromethyl ketone
- CAS Number: 210345-04-3
- Molecular Formula: C32H43FN6O10
- Molecular Weight: 690.71600
- Catalog: Signaling Pathways Apoptosis Caspase
- Create Date: 2017-11-19 04:29:14
- Modify Date: 2024-01-12 12:23:52
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Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3].
| Name | Z-Leu-Glu(OMe)-His-Asp(OMe) fluoromethyl ketone |
|---|---|
| Synonyms |
Z-LE(OMe)HD(OMe)-FMK
Z-LEHD-FMK |
| Description | Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Caspase-9 |
| In Vitro | Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity[1]. Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis[1]. Apoptosis Analysis[1] Cell Line: SW480, H460, HCT116 and 293 cells Concentration: 20 μM Incubation Time: Pretreated for 30 min Result: Protected HCT116 and 293 cells from TRAIL-induced apoptosis. Western Blot Analysis[1] Cell Line: HCT116, SW480 cells Concentration: 20 μM Incubation Time: 2 h Result: Protected procaspase 3 from cleavage in HCT116 cells but not in SW480 cells, especially at the 16-h time point. |
| In Vivo | Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats[2]. Animal Model: Male Wistar albino rats (250-350 g) with SCI[2] Dosage: 0.8 μmol/kg Administration: I.v. for 1 or 7 days Result: Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury. |
| References |
| Molecular Formula | C32H43FN6O10 |
|---|---|
| Molecular Weight | 690.71600 |
| Exact Mass | 690.30200 |
| PSA | 223.98000 |
| LogP | 2.36620 |