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176644-21-6

176644-21-6 structure
176644-21-6 structure
  • Name: Eniporide
  • Chemical Name: N-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-pyrrol-1-ylbenzamide
  • CAS Number: 176644-21-6
  • Molecular Formula: C14H16N4O3S
  • Molecular Weight: 320.37
  • Create Date: 2018-10-13 16:22:24
  • Modify Date: 2024-01-03 10:09:25
  • Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2].

Name N-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-pyrrol-1-ylbenzamide
Synonyms UNII-7IGF9182QU
Eniporide
N-(diaminomethylidene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide
N-Carbamimidoyl-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide
Benzamide, N-(aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)-
EMD96785
Description Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2].
Related Catalog
In Vitro ENIPORIDE 是一种有效的 Na+/H+ 交换抑制剂。
In Vivo Eniporide (3mg /kg;静脉注射;心脏骤停前全身输注) 可改善晶体性心脏骤停引起的缺血/再灌注健康猪心脏的功能和高能量磷酸盐含量[1]。 Animal Model: Clinically relevant pig models of cardiopulmonary bypass (CPB) and cardioplegia[1] Dosage: 3 mg/kg Administration: IV; systemic infusion before cardioplegia with added 2 μM Eniporide or not Result: Had no effect on standard hemodynamics including vascular pressures and cardiac index nor for cardiac performance factors. Reduced myocardial edema and improves heart function.
References

[1]. Zeymer U, et al. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38(6):1644-50.  

[2]. Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77(2):658-63.  

Density 1.4±0.1 g/cm3
Boiling Point 635.9±65.0 °C at 760 mmHg
Molecular Formula C14H16N4O3S
Molecular Weight 320.37
Flash Point 338.4±34.3 °C
Exact Mass 320.094299
PSA 128.92000
LogP 0.38
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.656
Storage condition 2-8°C
Hazard Codes Xi
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%