64480-66-6
64480-66-6 structure
- Name: Glycoursodeoxycholic acid
- Chemical Name: Glycoursodeoxycholic acid
- CAS Number: 64480-66-6
- Molecular Formula: C26H43NO5
- Molecular Weight: 449.62300
- Catalog: Natural product Steroidal compound
- Create Date: 2018-05-22 08:00:00
- Modify Date: 2026-07-01 20:28:21
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Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3].
| Name | Glycoursodeoxycholic acid |
|---|---|
| Synonyms |
3.α.,7.beta.-Dihydroxy-5.beta.-cholanoylglycine
Glycylursodeoxycholic acid Glycoursodeoxycholicaci 2-[[(4R)-4-[(3R,5S,7S,10R,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid Glycine, N-[(3a,5b,7b)-3,7-dihydroxy-24-oxocholan-24-yl] N-((3alpha,5beta,7beta)-7-Hydroxy-24-oxo-3-(sulfooxy)cholan-24-yl)glycine Glycoursodeoxycholic acid, 10 mM in DMSO Glycoursodeoxycholic acid (Ursodeoxycholylglycine) 2-[[(4R)-4-[(3R,5S,7S,8R,9R,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid N-[(3.α.,5.beta.,7.beta.)-3,7-Dihyd N-[(3.alpha.,5.beta.,7.beta.)-3,7-Dihyd N-[(3.alpha.,5.beta.,7.beta.)-3,7-dihydroxy-24-oxocholan-24-yl]Glycine N-(3α,7β-Dihydroxy-5β-cholan-24-oyl)glycine Glycoursodeoxycholic acid (6CI) 7-dihydroxy-10 GlycoursodeoxycholicAcid> N-(3.α.,7.beta.-Dihydroxy-5.beta.-cholan-24-oyl)glycine Ammonia BeDeoxycholic Acid inhibit,Endogenous Metabolite,Glycoursodeoxycholic acid,Inhibitor Ursodeoxycholylglycine Glyeoursodeoxycholie acid Glycyrtodeoxycholic acid Glycine ursodeoxycholic acid Glycoursodeoxycholic Acid (GUDCA) extrapure Glycoursodesoxycholic acid N-(3.alpha.,7.beta.-Dihydroxy-5.beta.-cholan-24-oyl)glycine Glycoursodeoxycholic-d4 Acid Glycinoursodeoxycholic acid Glycine cholic acid GUDCA N-[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]glycine Urosodeoxycholic Acid Impurity 19 5β-CHOLANIC ACID-3α, 7β-DIOL N-(CBOXYMETHYL)-AMIDE GLYCOURSODEOXYCHOLIC ACID N-(3α,7β-Dihydroxy-24-oxo-5β-cholan-24-yl)glycine 3.alpha.,7.beta.-Dihydroxy-5.beta.-cholanoylglycine 2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)acetic acid Glycoursodeoxycholic Acid N-Cboxymethyl-3α,7β-dihydroxy-5β-cholan-24-amide Glycine, N-[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl] 2-[[(4R)-4-[(3R,5S,7S,10R,13R,17R)-3,7-dihydroxy-10 Ursodeoxycholic Acid Impurity 2(Glycoursodeoxycholic Acid) N-[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]glycine, Glycylursodeoxycholic acid N-[(3.α.,5.beta.,7.beta.)-3,7-dihydroxy-24-oxocholan-24-yl]Glycine Glycoursodeoxycholic acidQ: What is Glycoursodeoxycholic acid Q: What is the CAS Number of Glycoursodeoxycholic acid Q: What is the storage condition of Glycoursodeoxycholic acid Q: What e the applications of Glycoursodeoxycholic acid 3-amino-1-azabicyclo[2.2.2]oct-3-yl diphenylacetate hydrochloride(1:1) glycoursodeoxycholate |
| Description | Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3]. |
|---|---|
| Related Catalog |
| Melting Point | 232-235ºC |
|---|---|
| Molecular Formula | C26H43NO5 |
| Molecular Weight | 449.62300 |
| Exact Mass | 449.31400 |
| PSA | 106.86000 |
| LogP | 3.98500 |
| Storage condition | -20°C Freezer |
| RIDADR | NONH for all modes of transport |
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