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52-49-3

52-49-3 structure
52-49-3 structure
  • Name: Benzhexol hydrochloride
  • Chemical Name: Benzhexol hydrochloride
  • CAS Number: 52-49-3
  • Molecular Formula: C20H32ClNO
  • Molecular Weight: 337.927
  • Catalog: API Nervous system medication Anti-shock palsy
  • Create Date: 2018-04-30 08:00:00
  • Modify Date: 2024-01-01 23:56:38
  • Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor.

Name Benzhexol hydrochloride
Synonyms 1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidinium chloride
1-Cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-olhydrochlorid
Trihexy
1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride (1:1)
UNII:AO61G82577
1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-olhydrochlorid
1-cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol hydrochloride
1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride (1:1)
pacitane
Broflex
(-)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride
1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol hydrochloride
pipanol
1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol hydrochloride (1:1)
1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride, (+)-
tremin
EINECS 205-614-4
Benzhexol HCL
Parkan
paralest
peragit
Sedrina
(+)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride
cyclodol
a-Cyclohexyl-a-phenyl-1-piperidinepropanol Hydrochloride
MFCD00058212
trihexylphenidyl HCl
1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride
1-cyclohexyl-1-phényl-3-pipéridin-1-ylpropan-1-ol chlorhydrate
D,L-Trihexyphenidyl Hydrochloride
1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride, (-)-
Trihexyphenidyl hydrochloride
Description Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor.
Related Catalog
Boiling Point 447.9ºC at 760mmHg
Melting Point 258.5ºC
Molecular Formula C20H32ClNO
Molecular Weight 337.927
Flash Point 211ºC
Exact Mass 337.217255
PSA 23.47000
LogP 5.07040
Appearance solid | white
Water Solubility H2O: soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TN2625000
CHEMICAL NAME :
1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-, hydrochloride
CAS REGISTRY NUMBER :
52-49-3
LAST UPDATED :
199706
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C20-H31-N-O.Cl-H
MOLECULAR WEIGHT :
337.98
WISWESSER LINE NOTATION :
T6NTJ A2XQR&- AL6TJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
800 ug/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis
REFERENCE :
BJPYAJ British Journal of Psychiatry. (Headley Brothers, Ltd., Ashford, Kent TN24 8HH, UK) V.109- 1963- Volume(issue)/page/year: 145,300,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
400 ug/kg/1W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,832,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1630 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (4),40,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
195 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
217 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 37,483,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
152 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - parasympatholytic
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,375,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5568 No. of Facilities: 59 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2666 (estimated) No. of Female Employees: 1339 (estimated)
Hazard Codes Xn
Risk Phrases R22
Safety Phrases S36
RIDADR 3249
WGK Germany 3
RTECS TN2625000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%