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23694-17-9

23694-17-9 structure
23694-17-9 structure
  • Name: Sultopride hydrochloride
  • Chemical Name: Sultopride Hydrochloride
  • CAS Number: 23694-17-9
  • Molecular Formula: C17H27ClN2O4S
  • Molecular Weight: 390.92500
  • Catalog: API Nervous system medication Antipsychotic
  • Create Date: 2018-02-13 08:00:00
  • Modify Date: 2024-01-06 08:06:39
  • Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor.
Name Sultopride Hydrochloride
Synonyms Sultopride hydrochloride
Description Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor.
Related Catalog
Target

Dopamine D2 receptor[1]
In Vivo Sultopride hydrochloride is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride hydrochloride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride hydrochloride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride hydrochloride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride hydrochloride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05)[1].
Animal Admin Thirty-six male Sprague-Dawley rats weighing 180 to 220 g are used in this study. The rats are divided into three groups of 6 each. One group is intraperitoneally injected with Sultopride hydrochloride (100 mg/kg body weight), the second group with sulphide (100 mg/kg body weight), and the third group with normal saline. One hundred minutes after the initial treatments, apomorphine (0.1 mg/kg body weight, dissolved in saline ad libitum) is administered subcutaneously to the three groups, and 20 minutes later the rats are sacrificed. The third group serves as controls[1].
References

[1]. Moriuchi K, et al. Differences in effects of sultopride and sulpiride on dopamine turnover in rat brain. Neurochem Res. 1995 Jan;20(1):95-9.
Density 1.16g/cm3
Boiling Point 530ºC
Melting Point 181-182ºC
Molecular Formula C17H27ClN2O4S
Molecular Weight 390.92500
Exact Mass 390.13800
PSA 84.09000
LogP 3.91450
Vapour Pressure 2.57E-11mmHg at 25°C
Storage condition Refrigerator
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 23694-17-9 | Chemsrc address: https://m.chemsrc.com/en/baike/889124.html

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