51014-29-0
51014-29-0 structure
- Name: Isocorynoxeine
- Chemical Name: methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
- CAS Number: 51014-29-0
- Molecular Formula: C22H26N2O4
- Molecular Weight: 382.453
- Catalog: Biochemical Chinese herbal medicine ingredients
- Create Date: 2018-08-08 19:14:57
- Modify Date: 2025-08-22 12:38:07
-
Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM.
| Name | methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate |
|---|---|
| Synonyms |
Methyl (16E,20α)-16-(methoxymethylene)-2-oxocorynox-18-en-17-oate
Y0112 17-methoxy-2-oxo-corynoxa-16,18-diene-16-carboxylic acid methyl ester Isocorynoxeine cisocorynoxeine |
| Description | Isocorynoxeine, an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. |
|---|---|
| Related Catalog | |
| Target |
5-HT2A Receptor:72.4 μM (IC50) |
| In Vitro | Isocorynoxeine inhibits 5-HT2A receptor-mediated 5-HT currents. Isocorynoxeine prefer to interact with 5-HT2A receptors rather than with 5-HT2C receptors in the brain.Isocorynoxeine exhibits less potent inhibitory activity (with IC50 values of > 100 μM) against the 5-HT2C receptor-mediated response than the 5-HT2A receptor-mediated response in oocytes. Isocorynoxeine dose-dependently and competitively inhibits 5-HT-evoked currents in Xenopus oocytes expressing 5-HT2A receptors, but has less of a suppressive effect on those in oocytes expressing 5-HT2C receptors[1]. |
| In Vivo | The effects of Rhynchophylline, Corynoxeine, and Isocorynoxeine, isorhynchophylline-related alkaloids present are tested in Uncaria species, on 5-MeO-DMT-induced head-twitch behaviour in reserpinized mice. Neither Rhynchophylline [H=1.369, P=0.504] nor Corynoxeine [H=0.242, P=0.886] affects the behaviour, while Isocorynoxeine significantly attenuates it at 30 mg/kg (i.p.) [H=7.582, P<0.01][1]. |
| Animal Admin | Mice[1] Male ICR mice are pretreated with Reserpine (5 mg/kg, i.p.) 3 h before the start of the experiments. Rhynchophylline (RHY), Corynoxeine (COX), Isocorynoxeine (ICOX, 10 and 30 mg/kg) or vehicle is injected i.p. 30 min before 5-MeO-DMT[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 562.7±50.0 °C at 760 mmHg |
| Molecular Formula | C22H26N2O4 |
| Molecular Weight | 382.453 |
| Flash Point | 294.1±30.1 °C |
| Exact Mass | 382.189270 |
| PSA | 71.36000 |
| LogP | 3.07 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.606 |
| Storage condition | -20°C |