20183-47-5
20183-47-5 structure
- Name: Tenuifolin
- Chemical Name: (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,2 8-dioic acid
- CAS Number: 20183-47-5
- Molecular Formula: C36H56O12
- Molecular Weight: 680.823
- Catalog: Biochemical Plant extracts
- Create Date: 2018-08-12 16:42:33
- Modify Date: 2026-06-30 14:30:34
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Tenuifolin is a triterpene isolated from Polygala tenuifolia Willd, has neuroprotective effects. Tenuifolin reduces Aβ secretion by inhibiting β-secretase. Tenuifolin improves learning and memory in aged mice by decreasing AChE activity and has the potential for Alzheimer’s disease (AD) treatment[1].
| Name | (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,2 8-dioic acid |
|---|---|
| Synonyms |
Tenuifolin from Polygala tenuifolia Willd
Tenuifolin, >= (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-24,28-dioic acid (2beta,3beta)-3-(beta-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,28-dioic Acid Tenuifoline 2β,27-Dihydroxy-3β-(β-D-glucopyranosyloxy)oleana-12-ene-23,28-dioic acid (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,28-dioic acid (2S,3R,4S,4,6,6bR,8aS,12aS,14,14bR)-2-Hydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-3-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14,14a,14b-octadecahydropicene-4,8a(1H)-dicboxylic acid Tenuifolin Impurity 1 (4S)-3β-(β-D-Glucopyranosyloxy)-2β,27-dihydroxyolean-12-ene-23,28-dioic acid 3β-(β-D-Glucopyranosyloxy)-2β,27-dihydroxyoleana-12-ene-23,28-dioic acid Polygonin tenuifolia Tenuifolin-RM Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, (2β,3β,4α) 2beta,27-Dihydroxy-3beta-(beta-D-glucopyranosyloxy)oleana-12-ene-23,28-dioic acid (2β,3β)-3-(β-D-Glucopyranosyloxy)-2,27-dihydroxyolean-12-ene-23,28-dioicaci |
| Description | Tenuifolin is a triterpene isolated from Polygala tenuifolia Willd, has neuroprotective effects. Tenuifolin reduces Aβ secretion by inhibiting β-secretase. Tenuifolin improves learning and memory in aged mice by decreasing AChE activity and has the potential for Alzheimer’s disease (AD) treatment[1]. |
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| Related Catalog | |
| Target |
IC50: β-secretase; ACHE[1] |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 853.6±65.0 °C at 760 mmHg |
| Melting Point | 201-204℃ |
| Molecular Formula | C36H56O12 |
| Molecular Weight | 680.823 |
| Flash Point | 262.2±27.8 °C |
| Exact Mass | 680.377197 |
| PSA | 214.44000 |
| LogP | 2.25 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.623 |
| Safety Phrases | 24/25 |
|---|---|
| HS Code | 29389090 |
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20183-47-5 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 30, # 3 p. 810 - 821 |
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20183-47-5 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 30, # 3 p. 810 - 821 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |